| Literature DB >> 26350270 |
J F Mendoza Rincón1, A K Rodríguez Elias2,3, J M Fragoso4, G Vargas Alarcón4, K Maldonado Murillo5, M L Rivas Jiménez6, R E Barbosa Cobos7, S Jimenez Morales8, G Lugo Zamudio9, C Tovilla Zárate10, J Ramírez Bello11.
Abstract
Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population. We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes. Our case-control study included 249 patients with RA and 314 controls. We found no evidence of an association between the MHC2TA -168G/A and +1614G/C or FCRL3 -169T/C polymorphisms and RA in this Mexican population. In this cohort of Mexican patients with RA, we observed no association between the MHC2TA or FCRL3 genes and this autoimmune disease.Entities:
Keywords: FCRL3; MHC2TA; Polymorphism; Rheumatoid arthritis
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Year: 2015 PMID： 26350270 DOI： 10.1007/s00296-015-3358-2
Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631