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Literature DB >> 17129777

Pathway to totipotency: lessons from germ cells.

Abstract

Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate all cell types after fertilization. Accumulating evidence suggests that this extraordinary potential is conferred to germ cells from the time of their formation during embryogenesis. In this Review, we describe common themes emerging from the study of germ cells in vertebrates and invertebrates. Transcriptional repression, chromatin remodeling, and an emphasis on posttranscriptional gene regulation preserve the totipotent genome of germ cells through generations.

Mesh：

Year: 2006 PMID： 17129777 DOI： 10.1016/j.cell.2006.11.016

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

166 in total

1. Bioinformatic analysis of P granule-related proteins: insights into germ granule evolution in nematodes.

Authors: Luis A Bezares-Calderón; Arturo Becerra; Laura S Salinas; Ernesto Maldonado; Rosa E Navarro
Journal: Dev Genes Evol Date: 2010-06-08 Impact factor: 0.900

Review 2. P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.

Authors: Carolyn J Decker; Roy Parker
Journal: Cold Spring Harb Perspect Biol Date: 2012-09-01 Impact factor: 10.005

3. A functional genomic screen in planarians identifies novel regulators of germ cell development.

Authors: Yuying Wang; Joel M Stary; James E Wilhelm; Phillip A Newmark
Journal: Genes Dev Date: 2010-09-15 Impact factor: 11.361

4. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.

Authors: Ekaterina Voronina; Geraldine Seydoux
Journal: Development Date: 2010-03-24 Impact factor: 6.868

5. A role for CHROMOMETHYLASE3 in mediating transposon and euchromatin silencing during egg cell reprogramming in Arabidopsis.

Authors: Marion Pillot; Daphné Autran; Olivier Leblanc; Daniel Grimanelli
Journal: Plant Signal Behav Date: 2010-10-01

Pathway to totipotency: lessons from germ cells.

1. Bioinformatic analysis of P granule-related proteins: insights into germ granule evolution in nematodes.

Review 2. P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.

3. A functional genomic screen in planarians identifies novel regulators of germ cell development.

4. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.

5. A role for CHROMOMETHYLASE3 in mediating transposon and euchromatin silencing during egg cell reprogramming in Arabidopsis.

6. Vasa genes: emerging roles in the germ line and in multipotent cells.

7. Small micromeres contribute to the germline in the sea urchin.

8. Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA.

Review 9. The epigenetics of germ-line immortality: lessons from an elegant model system.

Review 10. Germ Line Versus Soma in the Transition from Egg to Embryo.