Literature DB >> 17127061

Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.

Chang-Ming Sun1, Lee-Gin Lin, Hsi-Jung Yu, Chih-Yu Cheng, Ya-Chuan Tsai, Chi-Wei Chu, Yi-Hui Din, Yat-Pang Chau, Ming-Jaw Don.   

Abstract

A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.

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Year:  2006        PMID： 17127061     DOI： 10.1016/j.bmcl.2006.11.023

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Tubulin-interactive stilbene derivatives as anticancer agents.

Authors:  Renata Mikstacka; Tomasz Stefański; Jakub Różański
Journal:  Cell Mol Biol Lett       Date:  2013-07-01       Impact factor: 5.787

2.  Conversion of oximes to carbonyl compounds by triscetylpyridinium tetrakis(oxodiperoxotungsto) phosphate (PCWP)-mediated oxidation with hydrogen peroxide.

Authors:  Francesco P Ballistreri; Ugo Chiacchio; Antonio Rescifina; Gaetano Tomaselli; Rosa M Toscano
Journal:  Molecules       Date:  2008-06-01       Impact factor: 4.411

3.  Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.

Authors:  Virginia Spanò; Roberta Rocca; Marilia Barreca; Daniele Giallombardo; Alessandra Montalbano; Anna Carbone; Maria Valeria Raimondi; Eugenio Gaudio; Roberta Bortolozzi; Ruoli Bai; Pierfrancesco Tassone; Stefano Alcaro; Ernest Hamel; Giampietro Viola; Francesco Bertoni; Paola Barraja
Journal:  J Med Chem       Date:  2020-10-11       Impact factor: 7.446
  3 in total

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