Literature DB >> 17126420

Impairments in spatial memory retention of GFAP-apoE4 female mice.

Peter van Meer1, Summer Acevedo, Jacob Raber.   

Abstract

The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

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Year:  2006        PMID： 17126420      PMCID： PMC1950679          DOI： 10.1016/j.bbr.2006.10.024

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  21 in total

1.  Apolipoprotein E and cognitive performance.

Authors:  J Raber; D Wong; G Q Yu; M Buttini; R W Mahley; R E Pitas; L Mucke
Journal:  Nature       Date:  2000-03-23       Impact factor: 49.962

2.  Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.

Authors:  J F Diedrich; H Minnigan; R I Carp; J N Whitaker; R Race; W Frey; A T Haase
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

3.  Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

Authors:  Qin Xu; Aubrey Bernardo; David Walker; Tiffany Kanegawa; Robert W Mahley; Yadong Huang
Journal:  J Neurosci       Date:  2006-05-10       Impact factor: 6.167

4.  Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology.

Authors:  R E Hartman; D F Wozniak; A Nardi; J W Olney; L Sartorius; D M Holtzman
Journal:  Exp Neurol       Date:  2001-08       Impact factor: 5.330

5.  Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influences.

Authors:  W W Beatty
Journal:  Horm Behav       Date:  1979-04       Impact factor: 3.587

6.  Place navigation impaired in rats with hippocampal lesions.

Authors:  R G Morris; P Garrud; J N Rawlins; J O'Keefe
Journal:  Nature       Date:  1982-06-24       Impact factor: 49.962

7.  Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze.

Authors:  M Gallagher; R Burwell; M Burchinal
Journal:  Behav Neurosci       Date:  1993-08       Impact factor: 1.912

8.  Androgens protect against apolipoprotein E4-induced cognitive deficits.

Authors:  Jacob Raber; Gerold Bongers; Anthony LeFevour; Manuel Buttini; Lennart Mucke
Journal:  J Neurosci       Date:  2002-06-15       Impact factor: 6.167

9.  APOE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy.

Authors:  Yoshio Tsuboi; Keith A Josephs; Natalie Cookson; Dennis W Dickson
Journal:  Neurology       Date:  2003-01-28       Impact factor: 9.910

10.  Developments of a water-maze procedure for studying spatial learning in the rat.

Authors:  R Morris
Journal:  J Neurosci Methods       Date:  1984-05       Impact factor: 2.390
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  17 in total

1.  Oxidative stress impairs learning and memory in apoE knockout mice.

Authors:  Marianne Evola; Allyson Hall; Trevor Wall; Alice Young; Paula Grammas
Journal:  Pharmacol Biochem Behav       Date:  2010-05-08       Impact factor: 3.533

2.  Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Authors:  Haim Belinson; Zehavit Kariv-Inbal; Rakez Kayed; Eliezer Masliah; Daniel M Michaelson
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

3.  Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice.

Authors:  Jessica A Siegel; Michael J Craytor; Jacob Raber
Journal:  Behav Pharmacol       Date:  2010-10       Impact factor: 2.293

Review 4.  Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders.

Authors:  Suman Jayadev; Gwenn A Garden
Journal:  J Neuroimmune Pharmacol       Date:  2009-04-17       Impact factor: 4.147

5.  Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

Authors:  Lance A Johnson; Reid H J Olsen; Louise S Merkens; Andrea DeBarber; Robert D Steiner; Patrick M Sullivan; Nobuyo Maeda; Jacob Raber
Journal:  Neurobiol Dis       Date:  2014-01-09       Impact factor: 5.996

6.  Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice.

Authors:  Jessica A Siegel; Gwendolen E Haley; Jacob Raber
Journal:  Neurobiol Aging       Date:  2010-04-18       Impact factor: 4.673

7.  Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice.

Authors:  Ingrid Reverte; Fiona Peris-Sampedro; Pia Basaure; Leticia Campa; Cristina Suñol; Margarita Moreno; José Luis Domingo; Maria Teresa Colomina
Journal:  Psychopharmacology (Berl)       Date:  2016-01       Impact factor: 4.530

Review 8.  Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.

Authors:  Leo Ungar; Andre Altmann; Michael D Greicius
Journal:  Brain Imaging Behav       Date:  2014-06       Impact factor: 3.978

9.  ApoE isoform-dependent deficits in extinction of contextual fear conditioning.

Authors:  R H J Olsen; M Agam; M J Davis; J Raber
Journal:  Genes Brain Behav       Date:  2012-09-07       Impact factor: 3.449

Review 10.  AR, apoE, and cognitive function.

Authors:  Jacob Raber
Journal:  Horm Behav       Date:  2008-02-26       Impact factor: 3.587
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