Literature DB >> 1712235

Antiproliferative function of glia maturation factor beta.

R Lim1, W X Zhong, A Zaheer.   

Abstract

Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1712235      PMCID： PMC361655          DOI： 10.1091/mbc.1.10.741

Source DB:  PubMed          Journal:  Cell Regul        ISSN： 1044-2030


  24 in total

1.  Cyclic AMP as a mitogenic signal for cultured rat Schwann cells.

Authors:  M C Raff; A Hornby-Smith; J P Brockes
Journal:  Nature       Date:  1978-06-22       Impact factor: 49.962

2.  Tumor necrosis factors: gene structure and biological activities.

Authors:  D V Goeddel; B B Aggarwal; P W Gray; D W Leung; G E Nedwin; M A Palladino; J S Patton; D Pennica; H M Shepard; B J Sugarman
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1986

3.  Isolation and characterization of acidic and basic fibroblast growth factor.

Authors:  D Gospodarowicz
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

4.  Brain cells in culture: morphological transformation by a protein.

Authors:  R Lim; K Mitsunobu
Journal:  Science       Date:  1974-07-05       Impact factor: 47.728

5.  Maturation-stimulation effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture.

Authors:  R Lim; K Mitsunobu; W K Li
Journal:  Exp Cell Res       Date:  1973-04       Impact factor: 3.905

6.  Purification of rat Schwann cells from cultures of peripheral nerve: an immunoselective method using surfaces coated with anti-immunoglobulin antibodies.

Authors:  J G Assouline; E P Bosch; R Lim
Journal:  Brain Res       Date:  1983-10-31       Impact factor: 3.252

7.  An improved procedure for the isolation of glia maturation factor.

Authors:  R Lim; J F Miller
Journal:  J Cell Physiol       Date:  1984-06       Impact factor: 6.384

8.  Glia maturation factor promotes contact inhibition in cancer cells.

Authors:  R Lim; S Nakagawa; B G Arnason; D E Turriff
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

9.  Establishment and characterizaton of intestinal epithelial cell cultures.

Authors:  A Quaroni; R J May
Journal:  Methods Cell Biol       Date:  1980       Impact factor: 1.441

10.  Purification and preliminary characterization of a glial growth factor from the bovine pituitary.

Authors:  J P Brockes; G E Lemke; D R Balzer
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157
View more
  3 in total

1.  Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction.

Authors:  A Zaheer; W Zhong; E Y Uc; D R Moser; R Lim
Journal:  Cell Mol Neurobiol       Date:  1995-04       Impact factor: 5.046

2.  Identification of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) target proteins by proteome analysis: activation of EBNA2 in conditionally immortalized B cells reflects early events after infection of primary B cells by EBV.

Authors:  Martin Schlee; Tanja Krug; Olivier Gires; Reinhard Zeidler; Wolfgang Hammerschmidt; Reinhard Mailhammer; Gerhard Laux; Guido Sauer; Josip Lovric; Georg W Bornkamm
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

3.  Expressions of glia maturation factor-β by tumor cells and endothelia correlate with neovascularization and poor prognosis in human glioma.

Authors:  Xiao-Yan Kuang; Xue-Feng Jiang; Cong Chen; Xiao-Rui Su; Yu Shi; Jin-Rong Wu; Peng Zhang; Xin-Li Zhang; You-Hong Cui; Yi-Fang Ping; Xiu-Wu Bian
Journal:  Oncotarget       Date:  2016-12-27
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.