Literature DB >> 1712084

Influence of quinolinic acid, an endogenous neurotoxin, on a passive avoidance conditioned reflex in rats.

V L Kozlovskii1, O G Kenunen, I V Prakh'e.   

Abstract

Quinolinic acid, an endogenous neurotoxin, was introduced into the cerebral ventricles of a rat in doses of 0.5 microgram and 30 micrograms. The influence of the substance on the reproduction of a passive avoidance conditioned reflex (CR) was evaluated. It was found that a small dose of the preparation decreases extinction, while a large dose disrupts the reproduction of a passive avoidance CR. The disruption of the reproduction of the skill was also observed after bilateral electrolytic destruction of the dorsal hippocampus. Quinolinic degeneration of this structure exerted a substantial influence on the reproduction of a passive avoidance CR.

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Year:  1991        PMID： 1712084     DOI： 10.1007/bf01184233

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  10 in total

1.  Behavioral effects after ibotenic acid, 6-OHDA and electrolytic lesions in the central amygdala nucleus of the rat.

Authors:  F K Jellestad; A Markowska; H K Bakke; B Walther
Journal:  Physiol Behav       Date:  1986

2.  Differential vulnerability of central neurons of the rat to quinolinic acid.

Authors:  R Schwarcz; C Köhler
Journal:  Neurosci Lett       Date:  1983-07-15       Impact factor: 3.046

3.  Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS.

Authors:  T W Stone; M N Perkins
Journal:  Eur J Pharmacol       Date:  1981-07-10       Impact factor: 4.432

4.  Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: differences between rats and mice.

Authors:  I P Lapin; I B Prakhie; I P Kiseleva
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

5.  Neurotransmitters and memory: role of cholinergic, serotonergic, and noradrenergic systems.

Authors:  G Wenk; D Hughey; V Boundy; A Kim; L Walker; D Olton
Journal:  Behav Neurosci       Date:  1987-06       Impact factor: 1.912

6.  Colchicine-induced granule cell loss in rat hippocampus: selective behavioral and histological alterations.

Authors:  T J Walsh; D W Schulz; H A Tilson; D E Schmechel
Journal:  Brain Res       Date:  1986-11-19       Impact factor: 3.252

7.  Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

Authors:  R Schwarcz; W O Whetsell; R M Mangano
Journal:  Science       Date:  1983-01-21       Impact factor: 47.728

8.  Effects of altered cholinergic function on working and reference memory in the rat.

Authors:  R J Beninger; B A Wirsching; K Jhamandas; R J Boegman; S R el-Defrawy
Journal:  Can J Physiol Pharmacol       Date:  1986-03       Impact factor: 2.273

9.  Open field activity and passive avoidance responses in rats after lesion of the central amygdaloid nucleus by electrocoagulation and ibotenic acid.

Authors:  A S Riolobos; A I Martín García
Journal:  Physiol Behav       Date:  1987

10.  Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.

Authors:  M N Perkins; T W Stone
Journal:  J Pharmacol Exp Ther       Date:  1983-08       Impact factor: 4.030
  10 in total

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