Literature DB >> 17115187

A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families.

Lan-Juan Zhao1, Peng Xiao, Yong-Jun Liu, Dong-Hai Xiong, Hui Shen, Robert R Recker, Hong-Wen Deng.   

Abstract

To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

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Year:  2006        PMID： 17115187     DOI： 10.1007/s00439-006-0286-y

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

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Authors:  Yong-Jun Liu; Sonia Araujo; Robert R Recker; Hong-Wen Deng
Journal:  Curr Mol Med       Date:  2003-06       Impact factor: 2.222
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  9 in total

Review 1.  Molecular genetic studies of gene identification for sarcopenia.

Authors:  Li-Jun Tan; Shan-Lin Liu; Shu-Feng Lei; Christopher J Papasian; Hong-Wen Deng
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3.  The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.

Authors:  Mao Mao; Daniel R Thedens; Bo Chang; Belinda S Harris; Qing Yin Zheng; Kenneth R Johnson; Leah Rae Donahue; Michael G Anderson
Journal:  Mamm Genome       Date:  2009-08-08       Impact factor: 2.957

4.  Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate.

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Authors:  Yong-Jun Liu; Xiao-Gang Liu; Liang Wang; Christian Dina; Han Yan; Jian-Feng Liu; Shawn Levy; Christopher J Papasian; Betty M Drees; James J Hamilton; David Meyre; Jerome Delplanque; Yu-Fang Pei; Lei Zhang; Robert R Recker; Philippe Froguel; Hong-Wen Deng
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Authors:  B O Tayo; R Harders; A Luke; X Zhu; R S Cooper
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7.  Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.

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8.  Genome-wide linkage and regional association study of obesity-related phenotypes: the GenSalt study.

Authors:  Angela Y Liu; Dongfeng Gu; James E Hixson; Dabeeru C Rao; Lawrence C Shimmin; Cashell E Jaquish; De-Pei Liu; Jiang He; Tanika N Kelly
Journal:  Obesity (Silver Spring)       Date:  2013-07-02       Impact factor: 5.002

9.  Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.

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  9 in total

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