| Literature DB >> 17114435 |
Hiroyuki Hosokawa1, Motoko Y Kimura, Ryo Shinnakasu, Akane Suzuki, Takako Miki, Haruhiko Koseki, Maarten van Lohuizen, Masakatsu Yamashita, Toshinori Nakayama.
Abstract
The Polycomb group (PcG) gene products regulate the maintenance of the homeobox gene expression in Drosophila and vertebrates and also the cell cycle progression in thymocytes and Th2 cell differentiation in mature T cells. We herein studied the role of PcG gene bmi-1 product in Th1/Th2 cell differentiation and found that Bmi-1 facilitates Th2 cell differentiation in a Ring finger-dependent manner. Biochemical studies indicate that Bmi-1 interacts with GATA3 in T cells, which is dependent on the Ring finger of Bmi-1. The overexpression of Bmi-1 resulted in a decreased ubiquitination and an increased protein stability of GATA3. In bmi-1-deficient Th cells, the levels of Th2 cell differentiation decreased as the degradation and ubiquitination on GATA3 increased. Therefore, Bmi-1 plays a crucial role in the control of Th2 cell differentiation in a Ring finger-dependent manner by regulating GATA3 protein stability.Entities:
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Year: 2006 PMID： 17114435 DOI： 10.4049/jimmunol.177.11.7656
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422