Literature DB >> 17112792

The mechanics of base excision repair, and its relationship to aging and disease.

David M Wilson1, Vilhelm A Bohr.   

Abstract

Base excision repair (BER) is the major pathway responsible for averting the mutagenic and cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA damage. In particular, this pathway recognizes and repairs base modifications, such as uracil and 8-hydroxyguanine, as well as abasic sites and DNA single-strand breaks. In this review, we outline the basic mechanics of the BER process, and describe the potential association of this pathway with aging and age-related disease, namely cancer and neurodegeneration.

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Year:  2006        PMID： 17112792     DOI： 10.1016/j.dnarep.2006.10.017

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  136 in total

1.  Disconnecting XRCC1 and DNA ligase III.

Authors:  Sachin Katyal; Peter J McKinnon
Journal:  Cell Cycle       Date:  2011-07-15       Impact factor: 4.534

2.  The mitochondrial transcription factor A functions in mitochondrial base excision repair.

Authors:  Chandrika Canugovi; Scott Maynard; Anne-Cécile V Bayne; Peter Sykora; Jingyan Tian; Nadja C de Souza-Pinto; Deborah L Croteau; Vilhelm A Bohr
Journal:  DNA Repair (Amst)       Date:  2010-08-23

3.  Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle.

Authors:  Jonathan T Sczepanski; Remus S Wong; Jeffrey N McKnight; Gregory D Bowman; Marc M Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-13       Impact factor: 11.205

Review 4.  Does DNA repair occur during somatic hypermutation?

Authors:  Huseyin Saribasak; Patricia J Gearhart
Journal:  Semin Immunol       Date:  2012-06-22       Impact factor: 11.130

5.  8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

Authors:  Jixian Luo; Koa Hosoki; Attila Bacsi; Zsolt Radak; Muralidhar L Hegde; Sanjiv Sur; Tapas K Hazra; Allan R Brasier; Xueqing Ba; Istvan Boldogh
Journal:  Free Radic Biol Med       Date:  2014-03-26       Impact factor: 7.376

6.  Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.

Authors:  Omar R Alshykhly; Aaron M Fleming; Cynthia J Burrows
Journal:  Chem Res Toxicol       Date:  2015-09-02       Impact factor: 3.739

7.  The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.

Authors:  Wenjian Ma; Vijayalakshmi Panduri; Joan F Sterling; Bennett Van Houten; Dmitry A Gordenin; Michael A Resnick
Journal:  Mol Cell Biol       Date:  2008-12-15       Impact factor: 4.272

Review 8.  DNA strand breaks, neurodegeneration and aging in the brain.

Authors:  Sachin Katyal; Peter J McKinnon
Journal:  Mech Ageing Dev       Date:  2008-03-25       Impact factor: 5.432

9.  Recognition of abasic sites and single base bulges in DNA by a metalloinsertor.

Authors:  Brian M Zeglis; Jennifer A Boland; Jacqueline K Barton
Journal:  Biochemistry       Date:  2009-02-10       Impact factor: 3.162

Review 10.  DNA repair deficiency and neurological disease.

Authors:  Peter J McKinnon
Journal:  Nat Rev Neurosci       Date:  2009-01-15       Impact factor: 34.870
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