| Literature DB >> 17112593 |
Florin Marcel Musteata1, Janusz Pawliszyn.
Abstract
This review discusses the most recent developments and future challenges in the application of solid phase microextraction (SPME) for sampling of live biological samples. The emphasis is placed on applications of fiber SPME for analysis of volatile emissions and drugs in biological fluids. The method development section highlights the main parameters that need to be considered in the case of in vivo experiments: extraction techniques, selection of extraction phases, calibration procedures, determination of free concentrations, and automation.Mesh：
Substances：
Year: 2006 PMID： 17112593 DOI： 10.1016/j.jbbm.2006.07.006
Source DB: PubMed Journal: J Biochem Biophys Methods ISSN： 0165-022X