Literature DB >> 17110207

High-content screening: emerging hardware and software technologies.

Seungtaek Lee1, Bonnie J Howell.   

Abstract

The field of high-content screening has flourished since 2000 with advancements in automated fluorescence microscopy technologies, fluorescent labeling techniques, and sophisticated image analysis software. Through the use of these technologies, researchers can now monitor cellular and molecular events in individual cells in vitro following drug treatment or RNAi and rapidly screen compound and siRNA libraries. This chapter discusses current and next-generation hardware and software features and capabilities.

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Year:  2006        PMID： 17110207     DOI： 10.1016/S0076-6879(06)14025-2

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  11 in total

Review 1.  The potential of high-content high-throughput microscopy in drug discovery.

Authors:  V Starkuviene; R Pepperkok
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739

2.  High content cell screening in a microfluidic device.

Authors:  Raymond Cheong; Chiaochun Joanne Wang; Andre Levchenko
Journal:  Mol Cell Proteomics       Date:  2008-10-24       Impact factor: 5.911

Review 3.  Parallel imaging microfluidic cytometer.

Authors:  Daniel J Ehrlich; Brian K McKenna; James G Evans; Anna C Belkina; Gerald V Denis; David H Sherr; Man Ching Cheung
Journal:  Methods Cell Biol       Date:  2011       Impact factor: 1.441

Review 4.  New fluorescence microscopy methods for microbiology: sharper, faster, and quantitative.

Authors:  Zemer Gitai
Journal:  Curr Opin Microbiol       Date:  2009-04-06       Impact factor: 7.934

Review 5.  Small molecule modifiers of circadian clocks.

Authors:  Zheng Chen; Seung-Hee Yoo; Joseph S Takahashi
Journal:  Cell Mol Life Sci       Date:  2012-11-16       Impact factor: 9.261

6.  Automated cell identification and tracking using nanoparticle moving-light-displays.

Authors:  James A Tonkin; Paul Rees; Martyn R Brown; Rachel J Errington; Paul J Smith; Sally C Chappell; Huw D Summers
Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240

7.  Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Authors:  Sager J Gosai; Joon Hyeok Kwak; Cliff J Luke; Olivia S Long; Dale E King; Kevin J Kovatch; Paul A Johnston; Tong Ying Shun; John S Lazo; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  PLoS One       Date:  2010-11-12       Impact factor: 3.240

8.  Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening.

Authors:  Vebjorn Ljosa; Anne E Carpenter
Journal:  PLoS Comput Biol       Date:  2009-12-24       Impact factor: 4.475

9.  A versatile, bar-coded nuclear marker/reporter for live cell fluorescent and multiplexed high content imaging.

Authors:  Irina Krylova; Rachit R Kumar; Eric M Kofoed; Fred Schaufele
Journal:  PLoS One       Date:  2013-05-14       Impact factor: 3.240

10.  Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects.

Authors:  Adam T Szafran; Maria Szwarc; Marco Marcelli; Michael A Mancini
Journal:  PLoS One       Date:  2008-11-03       Impact factor: 3.240
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