| Literature DB >> 17110106 |
Jyoti R Patel1, Qi Shuai, Jurgen Dinges, Marty Winn, Marina Pliushchev, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Liping Pan, Seble Wagaw, Kenneth Engstrom, Francis A Kerdesky, Kenton Longenecker, Russell Judge, Wenying Qin, Hovis M Imade, Deanne Stolarik, David W A Beno, Michael Brune, Linda E Chovan, Hing L Sham, Peer Jacobson, J T Link.
Abstract
A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure-activity relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1 are discussed.Entities:
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Year: 2006 PMID： 17110106 DOI： 10.1016/j.bmcl.2006.10.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823