Clement C Y Tham1, Yolanda Y Y Kwong, Jimmy S M Lai, Dennis S C Lam. 1. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, People's Republic of China. clemtham@hkstar.com
Abstract
PURPOSE: To document the effect of a previous acute angle closure attack on the corneal endothelial cell density in chronic angle closure glaucoma (CACG) patients. METHODS: Consecutive cases of CACG with patent peripheral iridotomy had their central corneal endothelial cell density measured by specular microscopy. The corneal endothelial cell density of those CACG eyes with a previous documented acute angle closure attack were compared with those eyes without such a history, to determine the effect of a previous acute angle closure attack on corneal endothelial cell density. RESULTS: From July 2003 to July 2005, a total of 52 CACG eyes of 52 patients fulfilling the study criteria were recruited. Thirteen eyes (25%) had a previous documented acute angle closure attack, whereas 39 eyes (75%) did not. The mean central corneal endothelial cell density +/-1 standard deviation was 2271.7+/-312.9 (range, 1556 to 2661) cells/mm in those CACG eyes with previous acute angle closure, and 2570.0+/-429.9 (range, 1669 to 3861) cells/mm in those CACG eyes without previous acute angle closure (P < 0.05, Student t test). A previous acute angle closure attack in a CACG eye correlates with a 11.6% reduction in corneal endothelial cell density, compared with a CACG eye without such a history. There were no statistically significant differences between the 2 groups in age, LogMAR visual acuity, intraocular pressure, number of glaucoma eye drops, vertical cup-to-disk ratio, mean deviation or pattern standard deviation in Humphrey automated perimetry (P > 0.05). CONCLUSIONS: A previous acute angle closure attack correlates with a significantly reduced corneal endothelial cell density in CACG patients.
PURPOSE: To document the effect of a previous acute angle closure attack on the corneal endothelial cell density in chronic angle closure glaucoma (CACG) patients. METHODS: Consecutive cases of CACG with patent peripheral iridotomy had their central corneal endothelial cell density measured by specular microscopy. The corneal endothelial cell density of those CACG eyes with a previous documented acute angle closure attack were compared with those eyes without such a history, to determine the effect of a previous acute angle closure attack on corneal endothelial cell density. RESULTS: From July 2003 to July 2005, a total of 52 CACG eyes of 52 patients fulfilling the study criteria were recruited. Thirteen eyes (25%) had a previous documented acute angle closure attack, whereas 39 eyes (75%) did not. The mean central corneal endothelial cell density +/-1 standard deviation was 2271.7+/-312.9 (range, 1556 to 2661) cells/mm in those CACG eyes with previous acute angle closure, and 2570.0+/-429.9 (range, 1669 to 3861) cells/mm in those CACG eyes without previous acute angle closure (P < 0.05, Student t test). A previous acute angle closure attack in a CACG eye correlates with a 11.6% reduction in corneal endothelial cell density, compared with a CACG eye without such a history. There were no statistically significant differences between the 2 groups in age, LogMAR visual acuity, intraocular pressure, number of glaucoma eye drops, vertical cup-to-disk ratio, mean deviation or pattern standard deviation in Humphrey automated perimetry (P > 0.05). CONCLUSIONS: A previous acute angle closure attack correlates with a significantly reduced corneal endothelial cell density in CACG patients.
Authors: Hae-Young Lopilly Park; Na Young Lee; Chan Kee Park; Man Soo Kim Journal: Graefes Arch Clin Exp Ophthalmol Date: 2012-03-23 Impact factor: 3.117
Authors: Anthony J Aldave; Mark A Terry; Loretta B Szczotka-Flynn; Wendi Liang; Allison R Ayala; Maureen G Maguire; Robert C O'Brien; Beth Ann Benetz; John E Bokosky; Steven P Dunn; Thomas E Gillette; Kristin M Hammersmith; David R Hardten; Bennie H Jeng; Marc F Jones; Richard L Lindstrom; Kenneth J Maverick; Verinder S Nirankari; Matthew S Oliva; Irving M Raber; Christopher J Rapuano; George O D Rosenwasser; Kevin W Ross; John W Seedor; Neda Shamie; Christopher G Stoeger; Shachar Tauber; Woodford S Van Meter; David D Verdier; Jonathan H Lass Journal: Am J Ophthalmol Date: 2019-03-06 Impact factor: 5.258