| Literature DB >> 17103288 |
Abstract
Gender differences in alcohol-induced liver injury have been well described. Females develop alcoholic liver injury more rapidly and have a lower alcohol toxic threshold than men. The mechanism for this difference is poorly characterized, differences in first-pass metabolism in the stomach, or elimination rate, or alcohol distribution volume in the body have been suggested. In addition, estrogen has a major influence on the susceptibility of Kupffer cells to gut-derived LPS resulting in increased proinflammatory cytokine production, which could be a major contributing factor to the increased risk of women to alcohol-induced liver disease.Entities:
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Year: 2006 PMID: 17103288 DOI: 10.1007/s10354-006-0348-8
Source DB: PubMed Journal: Wien Med Wochenschr ISSN: 0043-5341