Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Polyamine induced aggregation of DNA.

Literature DB >> 17099

Polyamine induced aggregation of DNA.

Abstract

Polyamine induced aggregation of various DNAs has been studied under conditions usually employed in many enzymatic assays where DNA is one of the substrates. Spermine was by far the most efficient polyamine in causing aggregation followed by spermidine and cadaverine. All double-stranded and naturally occurring single-stranded DNAs were found to aggregate. No aggregation of single-stranded homodeoxypolymers could be detected under the same conditions. The concentration of polyamine at which the aggregation commenced was found to be a linear function of the DNA concentration. The slope of the curves depended on the nature of the polyamine, DNA the concentration of Mg++ and the ionic strength.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 17099 PMCID： PMC342472 DOI： 10.1093/nar/4.3.685

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

8 in total

1. Solubility of complexes of polynucleotides with spermine.

Authors: S L HUANG; G FELSENFELD
Journal: Nature Date: 1960-10-22 Impact factor: 49.962

2. The reaction of formaldehyde with nucleotides and T2 bacteriophage DNA.

Authors: L GROSSMAN; S S LEVINE; W S ALLISON
Journal: J Mol Biol Date: 1961-02 Impact factor: 5.469

3. Effect of salts and polyamines on T4 polynucleotide kinase.

Authors: J R Lillehaug; K Kleppe
Journal: Biochemistry Date: 1975-03-25 Impact factor: 3.162

4. Interaction between spermine and histones at nucleoprotein formation.

Authors: I Agrell; O Heby
Journal: Hoppe Seylers Z Physiol Chem Date: 1971-01

5. Observations on the affinity between polyamines and nucleic acids.

Authors: O Heby; I Agrell
Journal: Hoppe Seylers Z Physiol Chem Date: 1971-01

6. Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

Authors: R L O'Brien; J G Olenick; F E Hahn
Journal: Proc Natl Acad Sci U S A Date: 1966-06 Impact factor: 11.205

7. Kinetics and effect of salts and polyamines on T4 polynucleotide ligase.

Authors: A J Raae; R K Kleppe; K Kleppe
Journal: Eur J Biochem Date: 1975-12-15

8. Effects of polyamines and methylglyoxal bis(guanylhydrazone) on hepatic nuclear structure and deoxyribonucleic acid template activity.

Authors: K B Brown; N F Nelson; D G Brown
Journal: Biochem J Date: 1975-12 Impact factor: 3.857

8 in total

17 in total

1. Onset of DNA aggregation in presence of monovalent and multivalent counterions.

Authors: Yoram Burak; Gil Ariel; David Andelman
Journal: Biophys J Date: 2003-10 Impact factor: 4.033

Review 2. Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.

Authors: Paul A Janmey; David R Slochower; Yu-Hsiu Wang; Qi Wen; Andrejs Cēbers
Journal: Soft Matter Date: 2014-03-14 Impact factor: 3.679

3. Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.

Authors: Cyrus J Bacchi; Louis M Weiss; Schenella Lane; Benjamin Frydman; Aldonia Valasinas; Venodhar Reddy; Jerry S Sun; Laurence J Marton; Imitiaz A Khan; Magali Moretto; Nigel Yarlett; Murray Wittner
Journal: Antimicrob Agents Chemother Date: 2002-01 Impact factor: 5.191

Polyamine induced aggregation of DNA.

1. Solubility of complexes of polynucleotides with spermine.

2. The reaction of formaldehyde with nucleotides and T2 bacteriophage DNA.

3. Effect of salts and polyamines on T4 polynucleotide kinase.

4. Interaction between spermine and histones at nucleoprotein formation.

5. Observations on the affinity between polyamines and nucleic acids.

6. Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

7. Kinetics and effect of salts and polyamines on T4 polynucleotide ligase.

8. Effects of polyamines and methylglyoxal bis(guanylhydrazone) on hepatic nuclear structure and deoxyribonucleic acid template activity.

1. Onset of DNA aggregation in presence of monovalent and multivalent counterions.

Review 2. Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.

3. Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.

4. Precipitation of DNA by polyamines: a polyelectrolyte behavior.

5. DNA mesophases induced by spermidine: structural properties and biological implications.

Review 6. Polyamines and cancer: implications for chemotherapy and chemoprevention.

7. Ligand-induced DNA condensation: choosing the model.

8. Interhelical spacing in liquid crystalline spermine and spermidine-DNA precipitates.

9. Sealing of gaps in duplex DNA by T4 DNA ligase.

10. Polyamine-induced hydrolysis of apurinic sites in DNA and nucleosomes.