Literature DB >> 17095230

Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition.

David M Chenoweth1, Julie A Poposki, Michael A Marques, Peter B Dervan.   

Abstract

A series of hairpin oligomers containing benzimidazole (Bi) and imidazopyridine (Ip) rings were synthesized and screened to target 5'-WGGGGW-3', a core sequence in the DNA-binding site of NF-kappaB, a prolific transcription factor important in biology and disease. Five Bi and Ip containing oligomers bound to the 5'-WGGGGW-3' site with high affinity. One of the oligomers (Im-Im-Im-Im-gamma-Py-Bi-Py-Bi-beta-Dp) was able to inhibit DNA binding by the transcription factor NF-kappaB.

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Year:  2006        PMID： 17095230      PMCID： PMC3208330          DOI： 10.1016/j.bmc.2006.10.051

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  44 in total

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Review 7.  Natural and Synthetic Oligoarylamides: Privileged Structures for Medical Applications.

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8.  Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues.

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9.  Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions.

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  10 in total

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