Literature DB >> 17095222

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.

Peter Grundt1, Sarah Little Jane Husband, Robert R Luedtke, Michelle Taylor, Amy Hauck Newman.   

Abstract

A series of analogues of the dopamine D2 receptor antagonist L741,626 were synthesized and evaluated for binding and function at D2 family receptor subtypes. Several analogues showed comparable binding profiles to the parent ligand, however, in general, chemical modification served to reduce D2 binding affinity and selectivity.

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Year:  2006        PMID： 17095222      PMCID： PMC1851912          DOI： 10.1016/j.bmcl.2006.10.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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