| Literature DB >> 17095087 |
C Vaklavas1, A Tefferi, J Butterfield, R Ketterling, S Verstovsek, H Kantarjian, A Pardanani.
Abstract
In a study of 99 consecutive patients with "idiopathic" eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (approximately 8%) with an "Occult" T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.Entities:
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Year: 2006 PMID： 17095087 DOI： 10.1016/j.leukres.2006.10.005
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156