BACKGROUND: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS: We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter. RESULTS: Surprisingly, the mice develop B cell lymphomas in the majority of cases. CONCLUSION: These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype.
BACKGROUND: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS: We describe a novel transgenicmouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter. RESULTS: Surprisingly, the mice develop B cell lymphomas in the majority of cases. CONCLUSION: These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype.
Authors: Qian Zhang; Fang Wei; Hong Yi Wang; Xiaobin Liu; Darshan Roy; Qun-Bin Xiong; Shuguang Jiang; Andrew Medvec; Gwenn Danet-Desnoyers; Christopher Watt; Ewa Tomczak; Michael Kalos; James L Riley; Mariusz A Wasik Journal: Am J Pathol Date: 2013-12 Impact factor: 4.307
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Authors: Olaf Merkel; Frank Hamacher; Robert Griessl; Lisa Grabner; Ana-Iris Schiefer; Nicole Prutsch; Constance Baer; Gerda Egger; Michaela Schlederer; Peter William Krenn; Tanja Nicole Hartmann; Ingrid Simonitsch-Klupp; Christoph Plass; Philipp Bernhard Staber; Richard Moriggl; Suzanne D Turner; Richard Greil; Lukas Kenner Journal: J Pathol Date: 2015-04-27 Impact factor: 7.996