Literature DB >> 17092575

Facilitation by drug states does not depend on acquired excitatory strength.

Matthew I Palmatier1, Rick A Bevins.   

Abstract

Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4mg/kg), amphetamine (AMP, 1mg/kg), and chlordiazepoxide (CDP, 5mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.

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Year:  2006        PMID: 17092575      PMCID: PMC1800829          DOI: 10.1016/j.bbr.2006.10.015

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN: 0166-4328            Impact factor:   3.332


  28 in total

1.  Extinction and reacquisition of differential responding in rats trained to discriminate between chlordiazepoxide and saline.

Authors:  H J Rijnders; T U Järbe; J L Slangen
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

2.  Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

Authors:  George F Koob; Michel Le Moal
Journal:  Nat Neurosci       Date:  2005-11       Impact factor: 24.884

3.  Discriminative stimulus effects of d-amphetamine, methylphenidate, and diazepam in humans.

Authors:  S J Heishman; J E Henningfield
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Selective antagonism of behavioural effects of nicotine by dihydro-beta-erythroidine in rats.

Authors:  I P Stolerman; C J Chandler; H S Garcha; J M Newton
Journal:  Psychopharmacology (Berl)       Date:  1997-02       Impact factor: 4.530

5.  Facilitation by drug states does not depend on acquired excitatory strength.

Authors:  Matthew I Palmatier; Rick A Bevins
Journal:  Behav Brain Res       Date:  2006-11-07       Impact factor: 3.332

6.  Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: lack of acetaldehyde substitution.

Authors:  E Quertemont
Journal:  Behav Pharmacol       Date:  2003-07       Impact factor: 2.293

7.  Immunization to nicotine with a peptide-based vaccine composed of a conformationally biased agonist of C5a as a molecular adjuvant.

Authors:  Sam D Sanderson; Srinivasa R Cheruku; Maniyan P Padmanilayam; Jonathan L Vennerstrom; Geoffrey M Thiele; Matthew I Palmatier; Rick A Bevins
Journal:  Int Immunopharmacol       Date:  2003-01       Impact factor: 4.932

8.  Element pretraining influences the content of appetitive serial compound conditioning in rats.

Authors:  P C Holland
Journal:  J Exp Psychol Anim Behav Process       Date:  1985-07

9.  Drug states as discriminative stimuli in a flavor-aversion learning experiment.

Authors:  S Revusky; S Coombes; R W Pohl
Journal:  J Comp Physiol Psychol       Date:  1982-04

10.  Drug discrimination using a Pavlovian conditional discrimination paradigm in pigeons.

Authors:  B K Parker; D W Schaal; M Miller
Journal:  Pharmacol Biochem Behav       Date:  1994-12       Impact factor: 3.533

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  15 in total

1.  Sign- vs. goal-tracking in a feature positive discrimination task with nicotine: importance of spatial location of the conditional stimulus.

Authors:  Amanda M Dion; Carmela M Reichel; Rick A Bevins
Journal:  Behav Brain Res       Date:  2010-12-01       Impact factor: 3.332

Review 2.  Disentangling the nature of the nicotine stimulus.

Authors:  Rick A Bevins; Scott T Barrett; Robert J Polewan; Steven T Pittenger; Natashia Swalve; Sergios Charntikov
Journal:  Behav Processes       Date:  2011-11-24       Impact factor: 1.777

3.  Nicotine trained as a negative feature passes the retardation-of-acquisition and summation tests of a conditioned inhibitor.

Authors:  Jennifer E Murray; Andrew W Walker; Chia Li; Nicole R Wells; Rachel D Penrod; Rick A Bevins
Journal:  Learn Mem       Date:  2011-06-21       Impact factor: 2.460

4.  Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association.

Authors:  Jennifer E Murray; Rick A Bevins
Journal:  Behav Neurosci       Date:  2009-02       Impact factor: 1.912

5.  Pavlovian drug discrimination with bupropion as a feature positive occasion setter: substitution by methamphetamine and nicotine, but not cocaine.

Authors:  Jamie L Wilkinson; Chia Li; Rick A Bevins
Journal:  Addict Biol       Date:  2008-12-12       Impact factor: 4.280

6.  Pharmacological and non-pharmacological factors that regulate the acquisition of ketamine self-administration in rats.

Authors:  Marco Venniro; Anna Mutti; Cristiano Chiamulera
Journal:  Psychopharmacology (Berl)       Date:  2015-09-21       Impact factor: 4.530

7.  The interoceptive Pavlovian stimulus effects of caffeine.

Authors:  Jennifer E Murray; Chia Li; Matthew I Palmatier; Rick A Bevins
Journal:  Pharmacol Biochem Behav       Date:  2007-04-03       Impact factor: 3.533

8.  Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats.

Authors:  Jennifer E Murray; Nicole R Wells; George D Lyford; Rick A Bevins
Journal:  Psychopharmacology (Berl)       Date:  2009-06-04       Impact factor: 4.530

9.  Cocaine-induced behavioral sensitization and conditioning in male Japanese quail.

Authors:  Chana K Akins; Emily H Geary
Journal:  Pharmacol Biochem Behav       Date:  2007-10-09       Impact factor: 3.533

10.  Occasion setting by drug states: Functional equivalence following similar training history.

Authors:  Matthew I Palmatier; Rick A Bevins
Journal:  Behav Brain Res       Date:  2008-09-18       Impact factor: 3.332

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