Literature DB >> 17091371

Specificity of a DNA-based (DNAzyme) peroxidative biocatalyst.

Antonia M Rojas1, Pedro A Gonzalez, Eugene Antipov, Alexander M Klibanov.   

Abstract

A complex formation between hemin and a congruous oligonucleotide not only greatly enhances the former's peroxidative activity but also results in a biocatalyst (DNAzyme) with a novel specificity. Herein substrate, regio-, enantiomeric, and diastereomeric selectivities of heme, the DNAzyme, and the enzyme horseradish peroxidase are comparatively examined.

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Year:  2006        PMID： 17091371     DOI： 10.1007/s10529-006-9228-y

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  11 in total

1.  Highly L and D enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method.

Authors:  Eugene Antipov; Art E Cho; K Dane Wittrup; Alexander M Klibanov
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-12       Impact factor: 11.205

2.  A heme•DNAzyme activated by hydrogen peroxide catalytically oxidizes thioethers by direct oxygen atom transfer rather than by a Compound I-like intermediate.

Authors:  Nisreen M Shumayrikh; Jeffrey J Warren; Andrew J Bennet; Dipankar Sen
Journal:  Nucleic Acids Res       Date:  2021-02-26       Impact factor: 16.971

3.  Effect of Aptamer Binding on the Electron-Transfer Properties of Redox Cofactors.

Authors:  Ismaila Emahi; Paige R Gruenke; Dana A Baum
Journal:  J Mol Evol       Date:  2015-10-24       Impact factor: 2.395

4.  Heme activation by DNA: isoguanine pentaplexes, but not quadruplexes, bind heme and enhance its oxidative activity.

Authors:  Nisreen Shumayrikh; Yu Chuan Huang; Dipankar Sen
Journal:  Nucleic Acids Res       Date:  2015-03-30       Impact factor: 16.971

5.  Exploring the Use of a Guanine-Rich Catalytic DNA for Sulfoxide Preparation.

Authors:  María A Dellafiore; Javier M Montserrat; Adolfo M Iribarren
Journal:  PLoS One       Date:  2015-06-12       Impact factor: 3.240

6.  Double-stem Hairpin Probe and Ultrasensitive Colorimetric Detection of Cancer-related Nucleic Acids.

Authors:  Jianguo Xu; Hongling Li; Zai-Sheng Wu; Jun Qian; Chang Xue; Lee Jia
Journal:  Theranostics       Date:  2016-01-01       Impact factor: 11.556

7.  High specificity and tight spatial restriction of self-biotinylation by DNA and RNA G-Quadruplexes complexed in vitro and in vivo with Heme.

Authors:  Prince Kumar Lat; Kun Liu; Dev N Kumar; Kenneth K L Wong; Esther M Verheyen; Dipankar Sen
Journal:  Nucleic Acids Res       Date:  2020-06-04       Impact factor: 16.971

8.  G-quadruplex structures formed by expanded hexanucleotide repeat RNA and DNA from the neurodegenerative disease-linked C9orf72 gene efficiently sequester and activate heme.

Authors:  Jason C Grigg; Nisreen Shumayrikh; Dipankar Sen
Journal:  PLoS One       Date:  2014-09-10       Impact factor: 3.240

9.  Self-biotinylation of DNA G-quadruplexes via intrinsic peroxidase activity.

Authors:  Owen J Einarson; Dipankar Sen
Journal:  Nucleic Acids Res       Date:  2017-09-29       Impact factor: 16.971

Review 10.  Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications.

Authors:  Hidenobu Yaku; Takashi Murashima; Daisuke Miyoshi; Naoki Sugimoto
Journal:  Molecules       Date:  2012-09-05       Impact factor: 4.411
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