| Literature DB >> 17089047 |
Stefania Gelmini1, Melissa Poggesi, Pamela Pinzani, Sara Ciullini Mannurita, Fabio Cianchi, Rosa Valanzano, Claudio Orlando.
Abstract
We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epithelium of the same patients. Tankyrase-1 mRNA in colon cancers, as a mean, was significantly higher than in paired not affected tissues (p<0.0001), but its level correlates inversely with a cancer progression stage. Survival analysis indicated that lower Tankyrase-1 mRNA expression in colon cancers was significantly associated to reduced patient survival (p=0.019) and disease-free interval (p=0.035), confirmed also in a multi-variate analysis.Entities:
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Year: 2006 PMID： 17089047
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906