| Literature DB >> 17088059 |
Shyh-Ming Yang1, Ravi Malaviya, Lawrence J Wilson, Rochelle Argentieri, Xin Chen, Cangming Yang, Bingbing Wang, Druie Cavender, William V Murray.
Abstract
Simplification of bottom ring and regioselective functionalization of the indolocarbazole unit of staurosporine (2) are described. The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3). The structure-activity relationships (SAR) are discussed and a proposed binding model is also highlighted.Entities:
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Year: 2006 PMID： 17088059 DOI： 10.1016/j.bmcl.2006.10.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823