Literature DB >> 17085966

Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: cloning, sequencing, and characterization.

Devi Bahdur Basnet1, Tae-Jin Oh, Thi Thu Hang Vu, Basundhara Sthapit, Kwangkyoung Liou, Hei Chan Lee, Jin-Cheol Yoo, Jae Kyung Sohng.   

Abstract

The entire gene cluster involved in the biosynthesis of angucyclines Sch 47554 and Sch 47555 was cloned, sequenced, and characterized. Analysis of the nucleotide sequence of genomic DNA spanning 77.5-kb revealed a total of 55 open reading frames, and the deduced products exhibited strong sequence similarities to type II polyketide synthases, deoxysugar biosynthetic enzymes, and a variety of accessory enzymes. The involvement of this gene cluster in the pathway of Sch 47554 and Sch 47555 was confirmed by genetic inactivation of the aromatase, including a portion of the ketoreductase, which was disrupted by inserting the thiostrepton gene.

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Year:  2006        PMID： 17085966

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  15 in total

1.  Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator.

Authors:  Linqi Wang; Xiuyun Tian; Juan Wang; Haihua Yang; Keqiang Fan; Gangming Xu; Keqian Yang; Huarong Tan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-07       Impact factor: 11.205

Review 2.  The TetR family of regulators.

Authors:  Leslie Cuthbertson; Justin R Nodwell
Journal:  Microbiol Mol Biol Rev       Date:  2013-09       Impact factor: 11.056

Review 3.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

4.  Draft genome sequence of marine Streptomyces sp. strain W007, which produces angucyclinone antibiotics with a benz[a]anthracene skeleton.

Authors:  Song Qin; Hongyu Zhang; Fuchao Li; Benwei Zhu; Huajun Zheng
Journal:  J Bacteriol       Date:  2012-03       Impact factor: 3.490

5.  Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation.

Authors:  Gaiyun Zhang; Haibo Zhang; Sumei Li; Ji Xiao; Guangtao Zhang; Yiguang Zhu; Siwen Niu; Jianhua Ju; Changsheng Zhang
Journal:  Appl Environ Microbiol       Date:  2012-01-20       Impact factor: 4.792

6.  Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.

Authors:  Leonard Kaysser; Liane Lutsch; Stefanie Siebenberg; Emmanuel Wemakor; Bernd Kammerer; Bertolt Gust
Journal:  J Biol Chem       Date:  2009-04-07       Impact factor: 5.157

7.  Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.

Authors:  Igor Alexeev; Azmiri Sultana; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-29       Impact factor: 11.205

Review 8.  Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases.

Authors:  Jia Wang; Ruihua Zhang; Xin Chen; Xinxiao Sun; Yajun Yan; Xiaolin Shen; Qipeng Yuan
Journal:  Microb Cell Fact       Date:  2020-05-24       Impact factor: 5.328

9.  Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin.

Authors:  Wenwen Yang; Hongzhi Tang; Jun Ni; Qiulin Wu; Dongliang Hua; Fei Tao; Ping Xu
Journal:  PLoS One       Date:  2013-06-28       Impact factor: 3.240

10.  Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A.

Authors:  Irina Voitsekhovskaia; Constanze Paulus; Charlotte Dahlem; Yuriy Rebets; Suvd Nadmid; Josef Zapp; Denis Axenov-Gribanov; Christian Rückert; Maxim Timofeyev; Jörn Kalinowski; Alexandra K Kiemer; Andriy Luzhetskyy
Journal:  Microorganisms       Date:  2020-05-07
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