| Literature DB >> 17081031 |
Vijay Nair1, Manojkumar Poonoth, Sreekumar Vellalath, Eringathodi Suresh, Rajasekaran Thirumalai.
Abstract
A novel protocol for the annulation of tropone to enals involving nucleophilic heterocyclic carbene (NHC) catalyzed homoenolate formation has been developed. Interestingly, the reaction led to bicyclic delta-lactones instead of the expected gamma-spirolactones, presumably by the uncommon [8 + 3] annulation pathway. The strategy works well with a variety of enals.Entities:
Year: 2006 PMID： 17081031 DOI： 10.1021/jo0615706
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354