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Literature DB >> 17080994

Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.

Christopher A Gray¹, Simone P de Lira, Marcio Silva, Eli F Pimenta, Otavio H Thiemann, Glaucius Oliva, Eduardo Hajdu, Raymond J Andersen, Roberto G S Berlinck.

Abstract

Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 microM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons.

Entities: Chemical Disease

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Year: 2006 PMID： 17080994 DOI： 10.1021/jo060295k

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

9 in total

1. Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.

Authors: Lizbeth L L Parra; Ariane F Bertonha; Ivan R M Severo; Anna C C Aguiar; Guilherme E de Souza; Glaucius Oliva; Rafael V C Guido; Nathalia Grazzia; Tábata R Costa; Danilo C Miguel; Fernanda R Gadelha; Antonio G Ferreira; Eduardo Hajdu; Daniel Romo; Roberto G S Berlinck
Journal: J Nat Prod Date: 2018-01-03 Impact factor: 4.050

Review 2. Biological activities of meroterpenoids isolated from different sources.

Authors: Neeraj Kumar Fuloria; Radhika K Raheja; Kaushal H Shah; Manisha J Oza; Yogesh A Kulkarni; Vetriselvan Subramaniyan; Mahendran Sekar; Shivkanya Fuloria
Journal: Front Pharmacol Date: 2022-09-19 Impact factor: 5.988

Review 3. Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors: Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal: Biochim Biophys Acta Date: 2009-03-19

Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.

1. Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.

Review 2. Biological activities of meroterpenoids isolated from different sources.

4. Dolabelladienetriol, a compound from Dictyota pfaffii algae, inhibits the infection by Leishmania amazonensis.

5. Ethnopharmacological survey among migrants living in the Southeast Atlantic Forest of Diadema, São Paulo, Brazil.

Review 6. Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications.

7. A new 1,4-diazepine from South China Sea marine sponge Callyspongia species.

Review 8. Meroterpenes from marine invertebrates: structures, occurrence, and ecological implications.

Review 9. Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data.