Literature DB >> 17076847

Population-based audit of fresh-frozen plasma transfusion practices.

Riikka Palo1, Leena Capraro, Seppo Hovilehto, Merja Koivuranta, Tom Krusius, Elina Loponen, Ritva Mäntykoski, Jussi Pentti, Otto Pitkänen, Maria Raitakari, Jussi Rimpiläinen, Markku Salmenperä, Hanna Salo, Tiina Mäki.   

Abstract

BACKGROUND: In contrast to decreasing red blood cell (RBC) consumption in Finland, the use of fresh-frozen plasma (FFP) has been increasing since the 1990s, suggesting that FFP use may not always be optimal. To improve transfusion practices, knowledge of current FFP use and regional, national, and international comparison is necessary. STUDY DESIGN AND METHODS: Nine (of 21) Finnish hospital districts participated. Data concerning FFP-transfused patients in the years 2002 and 2003 were collected from existing computerized medical records into a yearly updated database as part of a Finnish benchmarking project on blood component use.
RESULTS: Data included 11,590 FFP-transfused patients and 60,240 FFP units (71.2% of Finnish FFP use) delivered to Finnish hospitals during the study period. FFP was transfused most often to surgery patients (62.8% of FFP transfusion hospital visits) with blood circulatory system problems (32.3% of surgically treated and FFP-transfused patients). In only 65.9 percent of FFP-transfused patients were coagulation variables measured at any point in the hospital episode, and FFP was usually transfused in paired doses. Mean FFP use in Finland is comparable to other countries.
CONCLUSION: Although overall FFP use in Finland is similar to that of international figures, it does not ensure best practice. Perioperative staff, being the largest FFP user, should be encouraged to dose FFP based on coagulation variables and body weight. Improvement efforts should be directed to patient groups transfused with large amounts of FFP.

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Year:  2006        PMID: 17076847     DOI: 10.1111/j.1537-2995.2006.00998.x

Source DB:  PubMed          Journal:  Transfusion        ISSN: 0041-1132            Impact factor:   3.157


  9 in total

1.  Rationalizing the clinical use of frozen plasma.

Authors:  Peter H Pinkerton; Jeannie L Callum
Journal:  CMAJ       Date:  2010-03-15       Impact factor: 8.262

2.  Tuscan study on the appropriateness of fresh-frozen plasma transfusion (TuSAPlaT).

Authors:  Giancarlo Maria Liumbruno; Maria Laura Sodini; Giuliano Grazzini
Journal:  Blood Transfus       Date:  2007-04       Impact factor: 3.443

3.  An audit of fresh frozen plasma usage and effect of fresh frozen plasma on the pre-transfusion international normalized ratio.

Authors:  S A Shinagare; N N Angarkar; S R Desai; M R Naniwadekar
Journal:  Asian J Transfus Sci       Date:  2010-07

4.  Prophylactic plasma transfusion for patients undergoing non-cardiac surgery.

Authors:  Jonathan Huber; Simon J Stanworth; Carolyn Doree; Marialena Trivella; Susan J Brunskill; Sally Hopewell; Kirstin L Wilkinson; Lise J Estcourt
Journal:  Cochrane Database Syst Rev       Date:  2017-08-17

5.  Audit of the clinical use of fresh-frozen plasma in Umbria: study design and results of the pilot phase.

Authors:  Alfonso Iorio; Michela Basileo; Emanuela Marchesini; Gian Paolo Palazzesi; Mario Materazzi; Mauro Marchesi; Antonella Esposito; Lucio Pellegrini; Antonella Germani; Lauretta Rocchetti; Carla Maria Silvani
Journal:  Blood Transfus       Date:  2008-10       Impact factor: 3.443

Review 6.  Fresh frozen plasma for cardiovascular surgery.

Authors:  Michael Desborough; Ravinda Sandu; Susan J Brunskill; Carolyn Doree; Marialena Trivella; Alessandro Montedori; Iosief Abraha; Simon Stanworth
Journal:  Cochrane Database Syst Rev       Date:  2015-07-14

7.  A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time.

Authors:  Simon J Stanworth; Timothy S Walsh; Robin J Prescott; Robert J Lee; Douglas M Watson; Duncan Wyncoll
Journal:  Crit Care       Date:  2011-04-05       Impact factor: 9.097

8.  Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing non-cardiac surgery or invasive procedures.

Authors:  Jonathan Huber; Simon J Stanworth; Carolyn Doree; Patricia M Fortin; Marialena Trivella; Susan J Brunskill; Sally Hopewell; Kirstin L Wilkinson; Lise J Estcourt
Journal:  Cochrane Database Syst Rev       Date:  2019-11-28

9.  Bleeding complications in cholecystectomy: a register study of over 22,000 cholecystectomies in Finland.

Authors:  S Suuronen; A Kivivuori; J Tuimala; H Paajanen
Journal:  BMC Surg       Date:  2015-08-13       Impact factor: 2.102

  9 in total

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