| Literature DB >> 17072829 |
Monica Rosa Loizzo1, Ataa Said, Rosa Tundis, Khaled Rashed, Giancarlo Antonio Statti, Antje Hufner, Francesco Menichini.
Abstract
In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), a plant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOH extract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol-3-O-alpha-arabinopyranoside, kaempferol-3-O-beta-galactopyranoside, quercetin-3-O-alpha-arabinopyranoside and luteolin-7-O-beta-glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compounds were elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most active compound was kaempferol-3-O-beta-galactopyranoside with an IC(50) value of 260 microm.Entities:
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Year: 2007 PMID： 17072829 DOI： 10.1002/ptr.2008
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878