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Literature DB >> 17072309

Molecular ablation of ventricular tachycardia after myocardial infarction.

Tetsuo Sasano¹, Amy D McDonald, Kan Kikuchi, J Kevin Donahue.

Abstract

Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.

Entities: Disease Gene Mutation

Mesh：

Substances：

Year: 2006 PMID： 17072309 PMCID： PMC1783685 DOI： 10.1038/nm1503

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

12 in total

1. Complications associated with implantable cardioverter-defibrillator replacement in response to device advisories.

Authors: Paul A Gould; Andrew D Krahn
Journal: JAMA Date: 2006-04-26 Impact factor: 56.272

2. Biological pacemaker created by gene transfer.

Authors: Junichiro Miake; Eduardo Marbán; H Bradley Nuss
Journal: Nature Date: 2002-09-12 Impact factor: 49.962

3. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors.

Authors: R O Snyder; C H Miao; G A Patijn; S K Spratt; O Danos; D Nagy; A M Gown; B Winther; L Meuse; L K Cohen; A R Thompson; M A Kay
Journal: Nat Genet Date: 1997-07 Impact factor: 38.330

4. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors.

Authors: T Kafri; U Blömer; D A Peterson; F H Gage; I M Verma
Journal: Nat Genet Date: 1997-11 Impact factor: 38.330

5. Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.

Authors: M D Lesh; M Pring; J F Spear
Journal: Circ Res Date: 1989-11 Impact factor: 17.367

6. Focal modification of electrical conduction in the heart by viral gene transfer.

Authors: J K Donahue; A W Heldman; H Fraser; A D McDonald; J M Miller; J J Rade; T Eschenhagen; E Marbán
Journal: Nat Med Date: 2000-12 Impact factor: 53.440

7. Radiofrequency catheter ablation of postinfarction ventricular tachycardia: long-term success and the significance of inducible nonclinical arrhythmias.

Authors: S A Rothman; H H Hsia; S F Cossú; I L Chmielewski; A E Buxton; J M Miller
Journal: Circulation Date: 1997-11-18 Impact factor: 29.690

8. Expression and function of a biological pacemaker in canine heart.

Authors: Jihong Qu; Alexei N Plotnikov; Peter Danilo; Iryna Shlapakova; Ira S Cohen; Richard B Robinson; Michael R Rosen
Journal: Circulation Date: 2003-03-04 Impact factor: 29.690

9. Avoidance of immune response prolongs expression of genes delivered to the adult rat myocardium by replication-defective adenovirus.

Authors: M J Quiñones; J Leor; R A Kloner; M Ito; M Patterson; W F Witke; L Kedes
Journal: Circulation Date: 1996-09-15 Impact factor: 29.690

10. In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype.

Authors: Michael Brunner; Sodikdjon A Kodirov; Gary F Mitchell; Peter D Buckett; Katsushi Shibata; Eduardo J Folco; Linda Baker; Guy Salama; Danny P Chan; Jun Zhou; Gideon Koren
Journal: Am J Physiol Heart Circ Physiol Date: 2003-07 Impact factor: 4.733

52 in total

Review 1. Regenerative therapies in electrophysiology and pacing: introducing the next steps.

Authors: Gerard J J Boink; Michael R Rosen
Journal: J Interv Card Electrophysiol Date: 2010-12-16 Impact factor: 1.900

2. Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.

Authors: Gerard J J Boink; Jia Lu; Helen E Driessen; Lian Duan; Eugene A Sosunov; Evgeny P Anyukhovsky; Iryna N Shlapakova; David H Lau; Tove S Rosen; Peter Danilo; Zhiheng Jia; Nazira Ozgen; Yevgeniy Bobkov; Yuanjian Guo; Peter R Brink; Yelena Kryukova; Richard B Robinson; Emilia Entcheva; Ira S Cohen; Michael R Rosen
Journal: Circ Arrhythm Electrophysiol Date: 2012-06-21

Review 9. Making better scar: Emerging approaches for modifying mechanical and electrical properties following infarction and ablation.

Authors: Jeffrey W Holmes; Zachary Laksman; Lior Gepstein
Journal: Prog Biophys Mol Biol Date: 2015-11-23 Impact factor: 3.667

10. Molecular mechanisms of inherited arrhythmias.

Authors: Cordula M Wolf; Charles I Berul
Journal: Curr Genomics Date: 2008-05 Impact factor: 2.236