Literature DB >> 17993320

Gene therapy approaches to ventricular tachyarrhythmias.

J Kevin Donahue1, Tetsuo Sasano, Kamilla Kelemen.   

Abstract

Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac arrhythmias. In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model.

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Year:  2007        PMID： 17993320      PMCID： PMC2121616          DOI： 10.1016/j.jelectrocard.2007.05.036

Source DB:  PubMed          Journal:  J Electrocardiol        ISSN： 0022-0736            Impact factor:   1.438


  24 in total

Review 1.  Catheter ablation of ventricular tachycardia in patients with coronary heart disease. Part II: Clinical aspects, limitations, and recent developments.

Authors:  E Delacrétaz; W G Stevenson
Journal:  Pacing Clin Electrophysiol       Date:  2001-09       Impact factor: 1.976

2.  Biological pacemaker created by gene transfer.

Authors:  Junichiro Miake; Eduardo Marbán; H Bradley Nuss
Journal:  Nature       Date:  2002-09-12       Impact factor: 49.962

3.  Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.

Authors:  Arthur J Moss; Wojciech Zareba; W Jackson Hall; Helmut Klein; David J Wilber; David S Cannom; James P Daubert; Steven L Higgins; Mary W Brown; Mark L Andrews
Journal:  N Engl J Med       Date:  2002-03-19       Impact factor: 91.245

4.  Catheter ablation of ventricular tachycardia in patients with structural heart disease using cooled radiofrequency energy: results of a prospective multicenter study. Cooled RF Multi Center Investigators Group.

Authors:  H Calkins; A Epstein; D Packer; A M Arria; J Hummel; D M Gilligan; J Trusso; M Carlson; R Luceri; H Kopelman; D Wilber; J M Wharton; W Stevenson
Journal:  J Am Coll Cardiol       Date:  2000-06       Impact factor: 24.094

5.  Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium.

Authors:  K Nagata; E Marbán; J H Lawrence; J K Donahue
Journal:  J Mol Cell Cardiol       Date:  2001-03       Impact factor: 5.000

6.  Expression and function of a biological pacemaker in canine heart.

Authors:  Jihong Qu; Alexei N Plotnikov; Peter Danilo; Iryna Shlapakova; Ira S Cohen; Richard B Robinson; Michael R Rosen
Journal:  Circulation       Date:  2003-03-04       Impact factor: 29.690

7.  Targeted high-efficiency, homogeneous myocardial gene transfer.

Authors:  Tetsuo Sasano; Kan Kikuchi; Amy D McDonald; Shenghan Lai; J Kevin Donahue
Journal:  J Mol Cell Cardiol       Date:  2007-02-14       Impact factor: 5.000

8.  Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

Authors:  T R Flotte; S A Afione; C Conrad; S A McGrath; R Solow; H Oka; P L Zeitlin; W B Guggino; B J Carter
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

9.  Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.

Authors:  D S Echt; P R Liebson; L B Mitchell; R W Peters; D Obias-Manno; A H Barker; D Arensberg; A Baker; L Friedman; H L Greene
Journal:  N Engl J Med       Date:  1991-03-21       Impact factor: 91.245

10.  Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy.

Authors:  Alan Kadish; Alan Dyer; James P Daubert; Rebecca Quigg; N A Mark Estes; Kelley P Anderson; Hugh Calkins; David Hoch; Jeffrey Goldberger; Alaa Shalaby; William E Sanders; Andi Schaechter; Joseph H Levine
Journal:  N Engl J Med       Date:  2004-05-20       Impact factor: 91.245
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  2 in total

Review 1.  Cardiac gene therapy: from concept to reality.

Authors:  Razmig Garo Kratlian; Roger J Hajjar
Journal:  Curr Heart Fail Rep       Date:  2012-03

2.  Distinguishing epicardial fat from scar: analysis of electrograms using high-density electroanatomic mapping in a novel porcine infarct model.

Authors:  Roderick Tung; Shiro Nakahara; Rafael Ramirez; Chi Lai; Michael C Fishbein; Kalyanam Shivkumar
Journal:  Heart Rhythm       Date:  2009-12-02       Impact factor: 6.343
  2 in total

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