| Literature DB >> 17070670 |
Abstract
The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of both ERalpha degradation and ERalpha-mediated transcriptional activation. Recent data will be summarized in this review. Models to explain the molecular mechanisms by which calmodulin modulates ERalpha function are proposed.Entities:
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Year: 2006 PMID: 17070670 DOI: 10.1016/j.cellsig.2006.08.018
Source DB: PubMed Journal: Cell Signal ISSN: 0898-6568 Impact factor: 4.315