| Literature DB >> 17070062 |
David C Pryde1, Andrew S Cook, Denise J Burring, Lyn H Jones, Stephanie Foll, Michelle Y Platts, Vivienne Sanderson, Martin Corless, Alan Stobie, Donald S Middleton, Laura Foster, Laura Barker, Piet Van Der Graaf, Peter Stacey, Christopher Kohl, Sara Coggon, Kevin Beaumont.
Abstract
A series of substituted glutaramides were synthesised using Candoxatrilat 1 as a lead and evaluated for potency against neutral endopeptidase (NEP) as a potential treatment for female sexual arousal disorder (FSAD). In this paper, we describe studies in which we were able to increase NEP activity substantially over the levels reported for previous compounds from this programme by appropriate substitution in both the P(1)(') and P(2)(') regions. Optimisation led to the 4-chlorophenpropylamide S-30 which was selected as a candidate for further study.Entities:
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Year: 2006 PMID： 17070062 DOI： 10.1016/j.bmc.2006.10.002
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641