Literature DB >> 170678

Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.

J S Flier, C R Kahn, J Roth, R S Bar.   

Abstract

Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.

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Year:  1975        PMID： 170678     DOI： 10.1126/science.170678

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  95 in total

1.  Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes.

Authors:  J C Lawrence; J Larner; C R Kahn; J Roth
Journal:  Mol Cell Biochem       Date:  1978-12-22       Impact factor: 3.396

Review 2.  Antibodies directed to the insulin receptor. Clinical aspects and applications to the study of insulin action.

Authors:  R De Pirro; P Borboni; M A Marini; A Montemurro; G Sesti; R Lauro
Journal:  J Endocrinol Invest       Date:  1990-12       Impact factor: 4.256

3.  Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.

Authors:  J S Flier; C R Kahn; D B Jarrett; J Roth
Journal:  J Clin Invest       Date:  1977-10       Impact factor: 14.808

Review 4.  Studies on the mechanism of insulin action: basic concepts and clinical implications.

Authors:  K D Hepp
Journal:  Diabetologia       Date:  1977-05       Impact factor: 10.122

5.  Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry.

Authors:  R Maron; S I Taylor; R Jackson; C R Kahn
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

6.  Endocrine abnormalities in a patient with partial trisomy 4q.

Authors:  M A Angulo; M Castro-Magana; J Sherman; P J Collipp; J Milson; C Trunca; A N Derenoncourt
Journal:  J Med Genet       Date:  1984-08       Impact factor: 6.318

7.  Serum from patients with pernicious anaemia blocks gastrin stimulation of acid secretion by parietal cells.

Authors:  H J de Aizpurua; B Ungar; B H Toh
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

8.  Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance.

Authors:  C Grunfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

9.  Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.

Authors:  F Hirata; R del Carmine; C A Nelson; J Axelrod; E Schiffmann; A Warabi; A L De Blas; M Nirenberg; V Manganiello; M Vaughan; S Kumagai; I Green; J L Decker; A D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

Review 10.  The treatment of hyperinsulinemic hypoglycaemia in adults: an update.

Authors:  M V Davi; A Pia; V Guarnotta; G Pizza; A Colao; A Faggiano
Journal:  J Endocrinol Invest       Date:  2016-09-13       Impact factor: 4.256
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