Literature DB >> 106236

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes.

J C Lawrence, J Larner, C R Kahn, J Roth.   

Abstract

Autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. The interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses.

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Year:  1978        PMID： 106236     DOI： 10.1007/bf00496241

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  30 in total

1.  Mechanism of cell entry and toxicity of an affinity- purified lectin from Ricinus communis and its differential effects on normal and virus-transformed fibroblasts.

Authors:  G L Nicolson; M Lacorbiere; T R Hunter
Journal:  Cancer Res       Date:  1975-01       Impact factor: 12.701

2.  Binding of insulin to isolated nuclei.

Authors:  I D Goldfine; G J Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

3.  Insulin-like activities and insulin-potentiating actions of a modified insulin B21-26 fragment: beta-Ala-Arg-Gly-Phe-Phe-Tyr-NH2.

Authors:  M Fujino; M Wakimasu; S Taketomi; H Iwatsuka
Journal:  Endocrinology       Date:  1977-08       Impact factor: 4.736

4.  Hormonal regulation of adipocyte enzymes. The effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase, and glycogen synthase.

Authors:  J C Khoo; D Steinberg; B Thompson; S E Mayer
Journal:  J Biol Chem       Date:  1973-06-10       Impact factor: 5.157

5.  Effects of antiinsulin receptor autoantibody on the metabolism of rat adipocytes.

Authors:  M Kasuga; Y Akanuma; T Tsushima; K Suzuki; K Kosaka; M Kibata
Journal:  J Clin Endocrinol Metab       Date:  1978-07       Impact factor: 5.958

6.  Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane.

Authors:  I D Goldfine; R Vigneri; D Cohen; N B Pliam; C R Kahn
Journal:  Nature       Date:  1977-10-20       Impact factor: 49.962

7.  Rat adipose tissue glycogen synthase. Evidence for multiple discrete kinetic species and their interconversion.

Authors:  R D Eichner
Journal:  J Biol Chem       Date:  1976-04-25       Impact factor: 5.157

8.  Receptors for peptide hormones. New insights into the pathophysiology of disease states in man.

Authors:  C R Kahn; K Megyesi; R S Bar; R C Eastman; J S Flier
Journal:  Ann Intern Med       Date:  1977-02       Impact factor: 25.391

9.  Interaction of insulin with the cell membrane: the primary action of insulin.

Authors:  P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1969-06       Impact factor: 11.205

10.  Insulin binding to rat liver Golgi fractions.

Authors:  J J Bergeron; W H Evans; I I Geschwind
Journal:  J Cell Biol       Date:  1973-12       Impact factor: 10.539
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  8 in total

1.  Anti-insulin receptor antibodies mimic the effects of insulin on the activities of pyruvate dehydrogenase and acetylCoA carboxylase and on specific protein phosphorylation in rat epididymal fat cells.

Authors:  G J Belsham; R W Brownsey; W A Hughes; R M Denton
Journal:  Diabetologia       Date:  1980-04       Impact factor: 10.122

Review 2.  A partial view of the mechanism of insulin action.

Authors:  R M Denton; R W Brownsey; G J Belsham
Journal:  Diabetologia       Date:  1981-10       Impact factor: 10.122

3.  Chemical mechanism of insulin action via proteolytic formation of mediator peptides.

Authors:  J Larner; K Cheng; C Schwartz; R Dubler; S Creacy; K Kikuchi; S Tamura; G Galasko; C Pullin; M Katz
Journal:  Mol Cell Biochem       Date:  1981-11-13       Impact factor: 3.396

4.  Independent control of selected insulin-sensitive cell membrane and intracellular functions - the linkage of cell membrane and intracellular events controlled by insulin. L. The influence of pH on insulin binding, membrane hexose transport and glycogen synthase activation.

Authors:  K Kikuchi; J Larner
Journal:  Mol Cell Biochem       Date:  1981-07-07       Impact factor: 3.396

5.  Independent control of selected insulin-sensitive cell membrane and intracellular functions-the linkage of cell membrane and intracellular events controlled by insulin. III. The influence of trypsin on cell membrane hexose transport and on glycogen synthase and mitochondrial pyruvate dehydrogenase activation.

Authors:  K Kikuchi; C Schwartz; S Creacy; J Larner
Journal:  Mol Cell Biochem       Date:  1981-07-07       Impact factor: 3.396

6.  Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.

Authors:  C Grunfeld; E Van Obberghen; F A Karlsson; C R Kahn
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

7.  The role of the insulin receptor in mediating the insulin-stimulated growth response in Reuber H-35 cells.

Authors:  J W Koontz
Journal:  Mol Cell Biochem       Date:  1984       Impact factor: 3.396

8.  Hepatic effects of glucose and insulin independent of cyclic nucleotide changes.

Authors:  M B Davidson; V Yoshii
Journal:  Acta Diabetol Lat       Date:  1981 Oct-Dec
  8 in total

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