| Literature DB >> 17067157 |
Wantana Mongkolvisut1, Somyote Sutthivaiyakit, Heiko Leutbecher, Sabine Mika, Iris Klaiber, Wolfgang Möller, Harald Rösner, Uwe Beifuss, Jürgen Conrad.
Abstract
Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 microM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.Entities:
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Year: 2006 PMID： 17067157 DOI： 10.1021/np0602012
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050