| Literature DB >> 17064892 |
Jeffrey S Condon1, Diane Joseph-McCarthy, Jeremy I Levin, Henry-Georges Lombart, Frank E Lovering, Linhong Sun, Weiheng Wang, Weixin Xu, Yuhua Zhang.
Abstract
By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.Entities:
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Year: 2006 PMID： 17064892 DOI： 10.1016/j.bmcl.2006.10.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823