Literature DB >> 170611

Relationship of the first step in protein synthesis to ppGpp: formation of A(5')ppp(5')Gpp.

E Rapaport, S K Svihovec, P C Zamecnik.   

Abstract

In the presence of purified Escherichia coli lysyl-tRNA synthetase [L-lysine:tRNALys ligase (AMP-forming) EC 6.1.1.6], L-lysine, and ATP, addition of the nucleotide ppGpp results in formation of a unique product-A(5')ppp(5') Gpp. The same compound is also formed very rapidly in a cell-free protein-synthesizing system when ppGpp is added. The possible significance of this reaction in the rapid turnover of ppGpp and as a more general mechanism by which an AMP residue is activated and introduced onto a 5'-diphosphorylated species, including the 5'-end of an RNA, is further discussed.

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Year:  1975        PMID： 170611      PMCID： PMC432828          DOI： 10.1073/pnas.72.7.2653

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  An enzymic mechanism for amino acid activation in animal tissues.

Authors:  M B HOAGLAND
Journal:  Biochim Biophys Acta       Date:  1955-02

2.  The occurrence of P1, P4-diguanosine 5'-tetraphosphate in brine shrimp eggs.

Authors:  F J FINAMORE; A H WARNER
Journal:  J Biol Chem       Date:  1963-01       Impact factor: 5.157

3.  Enzymatic carboxyl activation of amino acids.

Authors:  M B HOAGLAND; E B KELLER; P C ZAMECNIK
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

4.  Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.

Authors:  Y Furuichi; M Morgan; S Muthukrishnan; A J Shatkin
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

5.  Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

Authors:  C M Wei; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

6.  Codon specific, tRNA dependent in vitro synthesis of ppGpp and pppGpp.

Authors:  F S Pedersen; E Lund; N O Kjeldgaard
Journal:  Nat New Biol       Date:  1973-05-02

7.  Diguanosinetetraphosphatase from rat liver: Acitivity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate.

Authors:  C D Lobatón; C G Vallejo; A Sillero; M A Sillero
Journal:  Eur J Biochem       Date:  1975-01-15

8.  Isolation and characterization of dinucleoside tetra- and tri-phosphates formed in the presence of lysyl-sRNA synthetase.

Authors:  K Randerath; C M Janeway; M L Stephenson; P C Zamecnik
Journal:  Biochem Biophys Res Commun       Date:  1966-07-06       Impact factor: 3.575

9.  Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase.

Authors:  P C Zamecnik; M L Stephenson; C M Janeway; K Randerath
Journal:  Biochem Biophys Res Commun       Date:  1966-07-06       Impact factor: 3.575

10.  Synthesis and turnover of basal level guanosine tetraphosphate in Escherichia coli.

Authors:  J D Friesen; N P Fiil; K von Meyenburg
Journal:  J Biol Chem       Date:  1975-01-10       Impact factor: 5.157
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  7 in total

1.  Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator".

Authors:  E Rapaport; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

Review 2.  The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.

Authors:  R H Silverman; A G Atherly
Journal:  Microbiol Rev       Date:  1979-03

3.  Cell cycle variations of dinucleoside polyphosphates in synchronized cultures of mammalian cells.

Authors:  G Orfanoudakis; M Baltzinger; D Meyer; N Befort; J P Ebel; J J Befort; P Remy
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

4.  Occurence of nucleoside polyphosphates in rapidly labelled RNA preparations from radish seedlings (Raphanus sativus.).

Authors:  L Aspart-Pascot; M Delseny; Y Guitton
Journal:  Planta       Date:  1976-01       Impact factor: 4.116

5.  AppppA, heat-shock stress, and cell oxidation.

Authors:  P C Lee; B R Bochner; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

6.  Changes in diadenosine tetraphosphate levels in Physarum polycephalum with different oxygen concentrations.

Authors:  P N Garrison; S A Mathis; L D Barnes
Journal:  J Bacteriol       Date:  1989-03       Impact factor: 3.490

7.  The role of zinc in 5',5'-diadenosine tetraphosphate production by aminoacyl-transfer RNA synthetases.

Authors:  S Blanquet; P Plateau; A Brevet
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396
  7 in total

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