Literature DB >> 1684385

HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.

S Pang1, H V Vinters, T Akashi, W A O'Brien, I S Chen.   

Abstract

We investigated sequence variation in the human immunodeficiency virus type 1 (HIV-1) env gene region that encodes the fourth disulfide-bonded domain of the external membrane glycoprotein, gp120, among three HIV-1 isolates from patients with AIDS-related neurologic disease. The sequences of HIV-1 isolated directly from brain tissue, blood cells, and in vitro cell cultures were compared. The results suggest that there may be many closely related HIV-1 genomes of several distinct subtypes in an HIV-1-infected individual. Differences were observed in the frequency distribution of sequence variants obtained from brain versus blood of the same individuals. Overall, the proportion of silent mutations is much lower than expected by random occurrence. Taken together, these results favor the possibility that selective forces may play a role in the tissue distribution of certain HIV-1 strains.

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Year:  1991        PMID： 1684385

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr (1988)        ISSN： 0894-9255


  38 in total

1.  Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain.

Authors:  Tahar Babas; Daniel Muñoz; Joseph L Mankowski; Patrick M Tarwater; Janice E Clements; M Christine Zink
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

2.  Nonhomogeneous distribution of human immunodeficiency virus type 1 proviruses in the spleen.

Authors:  S Delassus; R Cheynier; S Wain-Hobson
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

Review 3.  Thinking about HIV: the intersection of virus, neuroinflammation and cognitive dysfunction.

Authors:  K Grovit-Ferbas; M E Harris-White
Journal:  Immunol Res       Date:  2010-12       Impact factor: 2.829

4.  In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues.

Authors:  J K Wong; C C Ignacio; F Torriani; D Havlir; N J Fitch; D D Richman
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

Review 5.  HIV evolution and escape.

Authors:  Douglas D Richman; Susan J Little; Davey M Smith; Terri Wrin; Christos Petropoulos; Joseph K Wong
Journal:  Trans Am Clin Climatol Assoc       Date:  2004

6.  The reverse transcriptase sequence of human immunodeficiency virus type 1 is under positive evolutionary selection within the central nervous system.

Authors:  Kelly J Huang; Gerald M Alter; Dawn P Wooley
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643

7.  In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.

Authors:  Y K Donaldson; J E Bell; E C Holmes; E S Hughes; H K Brown; P Simmonds
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

8.  Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences.

Authors:  C Power; J C McArthur; R T Johnson; D E Griffin; J D Glass; S Perryman; B Chesebro
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

9.  V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.

Authors:  S Y Chan; R F Speck; C Power; S L Gaffen; B Chesebro; M A Goldsmith
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

Review 10.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03
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