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Literature DB >> 17060635

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.

Jean J Zhao¹, Hailing Cheng, Shidong Jia, Li Wang, Ole V Gjoerup, Aki Mikami, Thomas M Roberts.

Abstract

Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110alpha, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110alpha, we generated mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that PIK3CA-knockout mouse embryonic fibroblasts are deficient in cellular signaling in response to various growth factors, unable to differentiate into adipocytes, and resistant to oncogenic transformation induced by a variety of oncogenic receptor tyrosine kinases, indicating a fundamental role for p110alpha in these biological processes.

Entities: Disease Gene Species

Mesh：

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Year: 2006 PMID： 17060635 PMCID： PMC1637576 DOI： 10.1073/pnas.0607899103

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

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Journal: Cell Date: 1997-05-02 Impact factor: 41.582

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Journal: Cell Date: 1986-06-06 Impact factor: 41.582

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Authors: H Land; L F Parada; R A Weinberg
Journal: Nature Date: 1983 Aug 18-24 Impact factor: 49.962

5. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

Authors: Khaled Ali; Antonio Bilancio; Matthew Thomas; Wayne Pearce; Alasdair M Gilfillan; Christine Tkaczyk; Nicolas Kuehn; Alexander Gray; June Giddings; Emma Peskett; Roy Fox; Ian Bruce; Christoph Walker; Carol Sawyer; Klaus Okkenhaug; Peter Finan; Bart Vanhaesebroeck
Journal: Nature Date: 2004-10-21 Impact factor: 49.962

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Authors: B Vanhaesebroeck; M J Welham; K Kotani; R Stein; P H Warne; M J Zvelebil; K Higashi; S Volinia; J Downward; M D Waterfield
Journal: Proc Natl Acad Sci U S A Date: 1997-04-29 Impact factor: 11.205

7. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

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Journal: Science Date: 2004-04-29 Impact factor: 47.728

8. Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

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Authors: D A Fruman; R E Meyers; L C Cantley
Journal: Annu Rev Biochem Date: 1998 Impact factor: 23.643

10. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

Authors: Zachary A Knight; Beatriz Gonzalez; Morri E Feldman; Eli R Zunder; David D Goldenberg; Olusegun Williams; Robbie Loewith; David Stokoe; Andras Balla; Balazs Toth; Tamas Balla; William A Weiss; Roger L Williams; Kevan M Shokat
Journal: Cell Date: 2006-04-27 Impact factor: 41.582

109 in total

1. Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

Authors: Lazaros C Foukas; Inma M Berenjeno; Alexander Gray; Asim Khwaja; Bart Vanhaesebroeck
Journal: Proc Natl Acad Sci U S A Date: 2010-06-07 Impact factor: 11.205

2. Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.

Authors: Chen Zhang; Bingfei Xu; Pian Liu
Journal: Tumour Biol Date: 2016-09-17

3. PI3K/mTOR signaling regulates prostatic branching morphogenesis.

Authors: Susmita Ghosh; Hiu Lau; Brian W Simons; Jonathan D Powell; David J Meyers; Angelo M De Marzo; David M Berman; Tamara L Lotan
Journal: Dev Biol Date: 2011-10-08 Impact factor: 3.582

Review 4. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Authors: Michele M Fluck; Brian S Schaffhausen
Journal: Microbiol Mol Biol Rev Date: 2009-09 Impact factor: 11.056

5. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Authors: Jennifer W Hill; Yong Xu; Frederic Preitner; Makota Fukuda; You-Ree Cho; Ji Luo; Nina Balthasar; Roberto Coppari; Lewis C Cantley; Barbara B Kahn; Jean J Zhao; Joel K Elmquist
Journal: Endocrinology Date: 2009-10-09 Impact factor: 4.736