Literature DB >> 17060532

In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci.

Wojciech Kamysz1, Carmela Silvestri, Oscar Cirioni, Andrea Giacometti, Alberto Licci, Agnese Della Vittoria, Marcin Okroj, Giorgio Scalise.   

Abstract

The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

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Year:  2006        PMID： 17060532      PMCID： PMC1797683          DOI： 10.1128/AAC.00344-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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  12 in total

1.  Short alkylated peptoid mimics of antimicrobial lipopeptides.

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Journal:  Antimicrob Agents Chemother       Date:  2010-10-18       Impact factor: 5.191

2.  Antibacterial properties and mode of action of a short acyl-lysyl oligomer.

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8.  Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides.

Authors:  Katarzyna E Greber; Malgorzata Dawgul; Wojciech Kamysz; Wieslaw Sawicki
Journal:  Front Microbiol       Date:  2017-02-01       Impact factor: 5.640

9.  In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity.

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10.  Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys-NH2 and an N-terminal Peptide of Human Lactoferricin on Biological Activity.

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