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Literature DB >> 17060514

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.

Lorraine Jones-Brando¹, John D'Angelo, Gary H Posner, Robert Yolken.

Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 17060514 PMCID： PMC1693994 DOI： 10.1128/AAC.00793-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia.

Authors: R H Yolken; S Bachmann; I Ruslanova; E Lillehoj; G Ford; E F Torrey; J Schroeder; I Rouslanova
Journal: Clin Infect Dis Date: 2001-02-28 Impact factor: 9.079

Review 2. A medicinal chemistry perspective on artemisinin and related endoperoxides.

Authors: Paul M O'Neill; Gary H Posner
Journal: J Med Chem Date: 2004-06-03 Impact factor: 7.446

3. In vitro effects of three new 1,2,4-trioxanes (pentatroxane, thiahexatroxane, and hexatroxanone) on Toxoplasma gondii.

Authors: H R Chang; C W Jefford; J C Pechère
Journal: Antimicrob Agents Chemother Date: 1989-10 Impact factor: 5.191

Review 4. Toxoplasma gondii: from animals to humans.

Authors: A M Tenter; A R Heckeroth; L M Weiss
Journal: Int J Parasitol Date: 2000-11 Impact factor: 3.981

5. Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii.

Authors: S Bachmann; J Schröder; C Bottmer; E F Torrey; R H Yolken
Journal: Psychopathology Date: 2005-04-22 Impact factor: 1.944

6. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii.

Authors: Lorraine Jones-Brando; E Fuller Torrey; Robert Yolken
Journal: Schizophr Res Date: 2003-08-01 Impact factor: 4.939

7. Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives.

Authors: O Y Ke; E C Krug; J J Marr; R L Berens
Journal: Antimicrob Agents Chemother Date: 1990-10 Impact factor: 5.191

8. In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.

Authors: E Holfels; J McAuley; D Mack; W K Milhous; R McLeod
Journal: Antimicrob Agents Chemother Date: 1994-06 Impact factor: 5.191

9. Antimalarial activity of new water-soluble dihydroartemisinin derivatives.

Authors: A J Lin; D L Klayman; W K Milhous
Journal: J Med Chem Date: 1987-11 Impact factor: 7.446

Review 10. Management of toxoplasmosis.

Authors: V S Georgiev
Journal: Drugs Date: 1994-08 Impact factor: 9.546

40 in total

1. Timing is everything for artemisinin action.

Authors: David J Sullivan
Journal: Proc Natl Acad Sci U S A Date: 2013-03-14 Impact factor: 11.205

Review 2. Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity.

Authors: Andrew J Neville; Sydney J Zach; Xiaofang Wang; Joshua J Larson; Abigail K Judge; Lisa A Davis; Jonathan L Vennerstrom; Paul H Davis
Journal: Antimicrob Agents Chemother Date: 2015-09-21 Impact factor: 5.191

3. Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii.

Authors: Kisaburo Nagamune; Wandy L Beatty; L David Sibley
Journal: Eukaryot Cell Date: 2007-08-31

4. Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii.

Authors: Akiko Ishiwa; Kyousuke Kobayashi; Hitoshi Takemae; Tatsuki Sugi; Haiyan Gong; Frances C Recuenco; Fumi Murakoshi; Atsuko Inomata; Taisuke Horimoto; Kentaro Kato
Journal: Parasitol Res Date: 2013-10-06 Impact factor: 2.289

Review 5. Recent advances in artemisinin production through heterologous expression.

Authors: Patrick R Arsenault; Kristin K Wobbe; Pamela J Weathers
Journal: Curr Med Chem Date: 2008 Impact factor: 4.530

6. DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures.

Authors: Abdul Mannan; Chunzhao Liu; Patrick R Arsenault; Melissa J Towler; Dan R Vail; Argelia Lorence; Pamela J Weathers
Journal: Plant Cell Rep Date: 2009-12-20 Impact factor: 4.570

7. Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.

Authors: John G D'Angelo; Claudia Bordón; Gary H Posner; Robert Yolken; Lorraine Jones-Brando
Journal: J Antimicrob Chemother Date: 2008-11-06 Impact factor: 5.790

8. Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.

Authors: Ravit Arav-Boger; Ran He; Chuang-Jiun Chiou; Jianyong Liu; Lauren Woodard; Andrew Rosenthal; Lorraine Jones-Brando; Michael Forman; Gary Posner
Journal: PLoS One Date: 2010-04-28 Impact factor: 3.240

Review 9. Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.

Authors: Madalyn M McFarland; Sydney J Zach; Xiaofang Wang; Lakshmi-Prasad Potluri; Andrew J Neville; Jonathan L Vennerstrom; Paul H Davis
Journal: Antimicrob Agents Chemother Date: 2016-11-21 Impact factor: 5.191

10. In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.

Authors: Martin Spicher; Carole Roethlisberger; Catharina Lany; Britta Stadelmann; Jennifer Keiser; Luis M Ortega-Mora; Bruno Gottstein; Andrew Hemphill
Journal: Antimicrob Agents Chemother Date: 2008-07-14 Impact factor: 5.191