C Winkler1, K Schroecksnadel, H Schennach, D Fuchs. 1. Division of Biological Chemistry, Biocentre, Innsbruck Medical University and Ludwig Boltzmann Institute for AIDS Research, Innsbruck, Austria.
Abstract
BACKGROUND/AIMS: The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS: In this study, the effects of vitamin C and E were investigated in unstimulated peripheral blood mononuclear cells and in cells stimulated with the mitogens phytohaemagglutinin and concanavalin A in vitro. RESULTS: The mitogens induced a significant production of neopterin and a degradation of tryptophan. Vitamin C (0.1-10 microM) and E (5-100 microM) suppressed these immunobiological pathways in a dose-dependent way (p < 0.01). CONCLUSION: Neopterin production and tryptophan degradation in monocyte-derived macrophages are both triggered by the pro-inflammatory cytokine interferon-gamma. Thus, their concurrent suppression by vitamin C and E suggests an effect on the formation and release of this cytokine by stimulated T cells. These findings may be related to the general health benefits which are associated with the antioxidant nature of these vitamins. Copyright 2007 S. Karger AG, Basel.
BACKGROUND/AIMS: The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS: In this study, the effects of vitamin C and E were investigated in unstimulated peripheral blood mononuclear cells and in cells stimulated with the mitogens phytohaemagglutinin and concanavalin A in vitro. RESULTS: The mitogens induced a significant production of neopterin and a degradation of tryptophan. Vitamin C (0.1-10 microM) and E (5-100 microM) suppressed these immunobiological pathways in a dose-dependent way (p < 0.01). CONCLUSION:Neopterin production and tryptophan degradation in monocyte-derived macrophages are both triggered by the pro-inflammatory cytokine interferon-gamma. Thus, their concurrent suppression by vitamin C and E suggests an effect on the formation and release of this cytokine by stimulated T cells. These findings may be related to the general health benefits which are associated with the antioxidant nature of these vitamins. Copyright 2007 S. Karger AG, Basel.
Authors: M Jenny; M Klieber; D Zaknun; S Schroecksnadel; K Kurz; M Ledochowski; H Schennach; Dietmar Fuchs Journal: Inflamm Res Date: 2010-08-26 Impact factor: 4.575
Authors: Lawrence E K Gray; Martin O'Hely; Sarath Ranganathan; Peter David Sly; Peter Vuillermin Journal: Front Immunol Date: 2017-03-31 Impact factor: 7.561