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Literature DB >> 17056742

Genetic architecture of Hsp90-dependent drug resistance.

Leah E Cowen¹, Anne E Carpenter, Oranart Matangkasombut, Gerald R Fink, Susan Lindquist.

Abstract

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2006 PMID： 17056742 PMCID： PMC1694807 DOI： 10.1128/EC.00274-06

Source DB: PubMed Journal: Eukaryot Cell ISSN： 1535-9786

28 in total

1. Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin.

Authors: J Imai; I Yahara
Journal: Mol Cell Biol Date: 2000-12 Impact factor: 4.272

2. CellProfiler: free, versatile software for automated biological image analysis.

Authors: Michael R Lamprecht; David M Sabatini; Anne E Carpenter
Journal: Biotechniques Date: 2007-01 Impact factor: 1.993

3. Plasmodium falciparum calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin.

Authors: Rajinder Kumar; Alla Musiyenko; Sailen Barik
Journal: Mol Biochem Parasitol Date: 2005-05 Impact factor: 1.759

4. Calcineurin is essential for survival during membrane stress in Candida albicans.

Authors: M Cristina Cruz; Alan L Goldstein; Jill R Blankenship; Maurizio Del Poeta; Dana Davis; Maria E Cardenas; John R Perfect; John H McCusker; Joseph Heitman
Journal: EMBO J Date: 2002-02-15 Impact factor: 11.598

5. Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

Authors: A Stathopoulos-Gerontides; J J Guo; M S Cyert
Journal: Genes Dev Date: 1999-04-01 Impact factor: 11.361

6. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

Authors: Chiatogu Onyewu; Floyd L Wormley; John R Perfect; Joseph Heitman
Journal: Infect Immun Date: 2004-12 Impact factor: 3.441

7. Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae.

Authors: Hiroyuki Yoshimoto; Kirstie Saltsman; Audrey P Gasch; Hong Xia Li; Nobuo Ogawa; David Botstein; Patrick O Brown; Martha S Cyert
Journal: J Biol Chem Date: 2002-06-10 Impact factor: 5.157

8. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.

Authors: Victoria L Heath; Sidney L Shaw; Sharmili Roy; Martha S Cyert
Journal: Eukaryot Cell Date: 2004-06

Review 9. Recombinant antibodies: a natural partner in combinatorial antifungal therapy.

Authors: Ruth C Matthews; James P Burnie
Journal: Vaccine Date: 2004-02-17 Impact factor: 3.641

Review 10. Hsp90: a specialized but essential protein-folding tool.

Authors: J C Young; I Moarefi; F U Hartl
Journal: J Cell Biol Date: 2001-07-23 Impact factor: 10.539

74 in total

Review 1. Post-translational modifications of Hsp90 and translating the chaperone code.

Authors: Sarah J Backe; Rebecca A Sager; Mark R Woodford; Alan M Makedon; Mehdi Mollapour
Journal: J Biol Chem Date: 2020-06-11 Impact factor: 5.157

2. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.

Authors: Francisco J Piña; Allyson F O'Donnell; Silvere Pagant; Hai Lan Piao; John P Miller; Stanley Fields; Elizabeth A Miller; Martha S Cyert
Journal: Eukaryot Cell Date: 2010-11-19

Review 3. Calcineurin regulation in fungi and beyond.

Authors: Jamal Stie; Deborah Fox
Journal: Eukaryot Cell Date: 2007-12-07

4. Dynamic duo takes down fungal villains.

Authors: Camile P Semighini; Joseph Heitman
Journal: Proc Natl Acad Sci U S A Date: 2009-02-26 Impact factor: 11.205

Review 5. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Authors: Leah E Cowen; William J Steinbach
Journal: Eukaryot Cell Date: 2008-03-28

6. Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses.

Authors: Drew D Dudgeon; Nannan Zhang; Olufisayo O Ositelu; Hyemin Kim; Kyle W Cunningham
Journal: Eukaryot Cell Date: 2008-09-19

Review 7. Decanalizing thinking on genetic canalization.

Authors: Kerry Geiler-Samerotte; Federica M O Sartori; Mark L Siegal
Journal: Semin Cell Dev Biol Date: 2018-05-24 Impact factor: 7.727

8. Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.

Authors: Frédéric Lamoth; Praveen R Juvvadi; Christopher Gehrke; Yohannes G Asfaw; William J Steinbach
Journal: J Infect Dis Date: 2013-10-04 Impact factor: 5.226

Review 9. Signaling cascades as drug targets in model and pathogenic fungi.

Authors: Robert J Bastidas; Jennifer L Reedy; Helena Morales-Johansson; Joseph Heitman; Maria E Cardenas
Journal: Curr Opin Investig Drugs Date: 2008-08

10. Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensing.

Authors: B N Singh; D K Upreti; B R Singh; G Pandey; S Verma; S Roy; A H Naqvi; A K S Rawat
Journal: Antimicrob Agents Chemother Date: 2015-02-02 Impact factor: 5.191