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Literature DB >> 15557662

The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

Chiatogu Onyewu¹, Floyd L Wormley, John R Perfect, Joseph Heitman.

Abstract

In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.

Entities: Chemical Gene Species

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Year: 2004 PMID： 15557662 PMCID： PMC529171 DOI： 10.1128/IAI.72.12.7330-7333.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

20 in total

1. Calcineurin is essential for survival during membrane stress in Candida albicans.

Authors: M Cristina Cruz; Alan L Goldstein; Jill R Blankenship; Maurizio Del Poeta; Dana Davis; Maria E Cardenas; John R Perfect; John H McCusker; Joseph Heitman
Journal: EMBO J Date: 2002-02-15 Impact factor: 11.598

2. Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans.

Authors: O Marchetti; P Moreillon; M P Glauser; J Bille; D Sanglard
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

3. A single-transformation gene function test in diploid Candida albicans.

Authors: B Enloe; A Diamond; A P Mitchell
Journal: J Bacteriol Date: 2000-10 Impact factor: 3.490

4. Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans.

Authors: O Marchetti; J M Entenza; D Sanglard; J Bille; M P Glauser; P Moreillon
Journal: Antimicrob Agents Chemother Date: 2000-11 Impact factor: 5.191

5. Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.

Authors: Leila M Boustany; Martha S Cyert
Journal: Genes Dev Date: 2002-03-01 Impact factor: 11.361

6. An improved transformation protocol for the human fungal pathogen Candida albicans.

Authors: Andrea Walther; Jürgen Wendland
Journal: Curr Genet Date: 2003-01-30 Impact factor: 3.886

7. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.

Authors: Chiatogu Onyewu; Jill R Blankenship; Maurizio Del Poeta; Joseph Heitman
Journal: Antimicrob Agents Chemother Date: 2003-03 Impact factor: 5.191

8. Comparison of caspofungin and amphotericin B for invasive candidiasis.

Authors: Jorge Mora-Duarte; Robert Betts; Coleman Rotstein; Arnaldo Lopes Colombo; Luis Thompson-Moya; Juanita Smietana; Robert Lupinacci; Carole Sable; Nicholas Kartsonis; John Perfect
Journal: N Engl J Med Date: 2002-12-19 Impact factor: 91.245

9. Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.

Authors: Dominique Sanglard; Françoise Ischer; Oscar Marchetti; José Entenza; Jacques Bille
Journal: Mol Microbiol Date: 2003-05 Impact factor: 3.501

10. Calcineurin is essential for Candida albicans survival in serum and virulence.

Authors: Jill R Blankenship; Floyd L Wormley; Molly K Boyce; Wiley A Schell; Scott G Filler; John R Perfect; Joseph Heitman
Journal: Eukaryot Cell Date: 2003-06

57 in total

1. Calcineurin is required for Candida albicans to survive calcium stress in serum.

Authors: Jill R Blankenship; Joseph Heitman
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

2. Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.

Authors: Taiga Miyazaki; Shunsuke Yamauchi; Tatsuo Inamine; Yosuke Nagayoshi; Tomomi Saijo; Koichi Izumikawa; Masafumi Seki; Hiroshi Kakeya; Yoshihiro Yamamoto; Katsunori Yanagihara; Yoshitsugu Miyazaki; Shigeru Kohno
Journal: Antimicrob Agents Chemother Date: 2010-01-25 Impact factor: 5.191

Review 3. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Authors: Leah E Cowen; William J Steinbach
Journal: Eukaryot Cell Date: 2008-03-28

Review 4. Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species.

Authors: Sharon C-A Chen; Russell E Lewis; Dimitrios P Kontoyiannis
Journal: Virulence Date: 2011-07-01 Impact factor: 5.882