| Literature DB >> 17056111 |
Meilani Syampurnawati1, Eiji Tatsumi, Kaho Furuta, Mariko Takenokuchi, Yuji Nakamachi, Seiji Kawano, Shunichi Kumagai, Katsuyasu Saigo, Toshimitsu Matsui, Takayuki Takahashi, Ken-Ichi Nagai, Hiroki Yabe, Shinichi Kondo, Yoshitake Hayashi.
Abstract
FLT3 mutations and cell-surface antigen were investigated in 29 DR-negative (DR(-)) M1/M2 AML samples in comparison with 30 DR-positive (DR(+)) M1/M2 AML samples. FLT3-ITD was detected in 59.3% and D835 was detected in 7.4% of the samples. The incidence of FLT3-ITD was higher in the DR(-) group (59.3%) than in the DR(+) group (17.9%; P=0.002). The DR(-) status was associated with the CD34(-) (82.8%), CD7(-) (92.9%) and CD45RO(+) status (76%). Our results indicated that FLT3 mutation is the most common gene alteration found in the DR(-) M1/M2 AML. These results are important for further characterizing this phenotypic AML entity.Entities:
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Year: 2006 PMID： 17056111 DOI： 10.1016/j.leukres.2006.09.017
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156