Literature DB >> 17055271

Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.

Olga Danilova1, Bei Li, A Katrin Szardenings, Brigitte T Huber, Jonathan S Rosenblum.   

Abstract

A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.

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Year:  2006        PMID： 17055271      PMCID： PMC1828633          DOI： 10.1016/j.bmcl.2006.10.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

1.  Dipeptidyl peptidase II and leukocyte cell death.

Authors:  Marie-Berthe Maes; Wim Martinet; Dorien M Schrijvers; Pieter Van der Veken; Guido R Y De Meyer; Koen Augustyns; Anne-Marie Lambeir; Simon Scharpé; Ingrid De Meester
Journal:  Biochem Pharmacol       Date:  2006-04-25       Impact factor: 5.858

2.  NF-kappaB signals induce the expression of c-FLIP.

Authors:  O Micheau; S Lens; O Gaide; K Alevizopoulos; J Tschopp
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

3.  Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase.

Authors:  R Underwood; M Chiravuri; H Lee; T Schmitz; A K Kabcenell; K Yardley; B T Huber
Journal:  J Biol Chem       Date:  1999-11-26       Impact factor: 5.157

4.  Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV.

Authors:  Christina Olsen; Nicolai Wagtmann
Journal:  Gene       Date:  2002-10-16       Impact factor: 3.688

5.  Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase.

Authors:  M Chiravuri; F Agarraberes; S L Mathieu; H Lee; B T Huber
Journal:  J Immunol       Date:  2000-11-15       Impact factor: 5.422

6.  Distinct pathways for stimulation of cytochrome c release by etoposide.

Authors:  J D Robertson; V Gogvadze; B Zhivotovsky; S Orrenius
Journal:  J Biol Chem       Date:  2000-10-20       Impact factor: 5.157

7.  Expression, purification, and kinetic characterization of full-length human fibroblast activation protein.

Authors:  Shaoxian Sun; Charles F Albright; Barbara H Fish; Henry J George; Bernard H Selling; Gregory F Hollis; Richard Wynn
Journal:  Protein Expr Purif       Date:  2002-03       Impact factor: 1.650

8.  Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator.

Authors:  Zia Shariat-Madar; Fakhri Mahdi; Alvin H Schmaier
Journal:  J Biol Chem       Date:  2002-02-05       Impact factor: 5.157

9.  Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.

Authors:  E G Duysen; B Li; W Xie; L M Schopfer; R S Anderson; C A Broomfield; O Lockridge
Journal:  J Pharmacol Exp Ther       Date:  2001-11       Impact factor: 4.030

10.  Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.

Authors:  Barbara Leiting; KellyAnn D Pryor; Joseph K Wu; Frank Marsilio; Reshma A Patel; Charles S Craik; Jonathan A Ellman; Richard T Cummings; Nancy A Thornberry
Journal:  Biochem J       Date:  2003-04-15       Impact factor: 3.857
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  5 in total

Review 1.  The metabolic serine hydrolases and their functions in mammalian physiology and disease.

Authors:  Jonathan Z Long; Benjamin F Cravatt
Journal:  Chem Rev       Date:  2011-06-23       Impact factor: 60.622

2.  Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia.

Authors:  Alexey V Danilov; Olga V Danilova; Jennifer R Brown; Arthur Rabinowitz; Andreas K Klein; Brigitte T Huber
Journal:  Exp Hematol       Date:  2010-09-24       Impact factor: 3.084

3.  S28 peptidases: lessons from a seemingly 'dysfunctional' family of two.

Authors:  John W Kozarich
Journal:  BMC Biol       Date:  2010-06-28       Impact factor: 7.431

4.  DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.

Authors:  Marian C Okondo; Darren C Johnson; Ramya Sridharan; Eun Bin Go; Ashley J Chui; Mitchell S Wang; Sarah E Poplawski; Wengen Wu; Yuxin Liu; Jack H Lai; David G Sanford; Michael O Arciprete; Todd R Golub; William W Bachovchin; Daniel A Bachovchin
Journal:  Nat Chem Biol       Date:  2016-11-07       Impact factor: 15.040

5.  Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.

Authors:  Gustavo Arruda Bezerra; Elena Dobrovetsky; Aiping Dong; Almagul Seitova; Lissete Crombett; Lisa M Shewchuk; Annie M Hassell; Sharon M Sweitzer; Thomas D Sweitzer; Patrick J McDevitt; Kyung O Johanson; Karen M Kennedy-Wilson; Doug Cossar; Alexey Bochkarev; Karl Gruber; Sirano Dhe-Paganon
Journal:  PLoS One       Date:  2012-08-29       Impact factor: 3.240
  5 in total

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