BACKGROUND: CYP1A1, one of the key enzymes in detoxifying toxic components produced during cigarette smoking, is regulated by aromatic hydrocarbon receptor (AHR). A CYP1A1 T3801C polymorphism, associated with a higher CYP1A1 inducibility and enhanced catalytic activity, has been linked to stroke, triple vessel disease and may, therefore, be associated with blood pressure (BP). The relation of the widely studied G1661A polymorphism of the human AHR gene with BP is unknown. OBJECTIVES: To investigate the genetic influence of CYP1A1 T3801C and AHR G1661A polymorphisms on BP in relation to tobacco consumption. DESIGN AND PARTICIPANTS: Study participants were selected from a French longitudinal cohort of volunteers for a free health check-up. These individuals (302 men and 311 women) were not taking medication that can affect blood pressure. Information about active smoking status was obtained by a self-administered questionnaire. RESULTS: After multiple regression analysis, systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not differ significantly according to their tobacco status excepted for DBP in men. In addition, neither CYP1A1 T3801C nor AHR G1661A polymorphism was linked to blood pressure. However, systolic and diastolic blood pressures differed significantly according to CYP1A1 T3801C genotype between ex-smokers and smokers. Finally, the interaction between CYP1A1 T3801C and AHR G1661A polymorphisms explained a significant difference of SBP and DBP between carriers of both CYP1A1-C3801 and AHR-A1661 alleles. CONCLUSION: This study is the first to show an interaction between the CYP1A1 T3801C and AHR G1661A polymorphisms. This interaction could explain the difference in blood pressure level between smokers and non-smokers/ex-smokers but needs to be confirmed in a large sample.
BACKGROUND:CYP1A1, one of the key enzymes in detoxifying toxic components produced during cigarette smoking, is regulated by aromatic hydrocarbon receptor (AHR). A CYP1A1T3801C polymorphism, associated with a higher CYP1A1 inducibility and enhanced catalytic activity, has been linked to stroke, triple vessel disease and may, therefore, be associated with blood pressure (BP). The relation of the widely studied G1661A polymorphism of the humanAHR gene with BP is unknown. OBJECTIVES: To investigate the genetic influence of CYP1A1T3801C and AHRG1661A polymorphisms on BP in relation to tobacco consumption. DESIGN AND PARTICIPANTS: Study participants were selected from a French longitudinal cohort of volunteers for a free health check-up. These individuals (302 men and 311 women) were not taking medication that can affect blood pressure. Information about active smoking status was obtained by a self-administered questionnaire. RESULTS: After multiple regression analysis, systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not differ significantly according to their tobacco status excepted for DBP in men. In addition, neither CYP1A1T3801C nor AHRG1661A polymorphism was linked to blood pressure. However, systolic and diastolic blood pressures differed significantly according to CYP1A1T3801C genotype between ex-smokers and smokers. Finally, the interaction between CYP1A1T3801C and AHRG1661A polymorphisms explained a significant difference of SBP and DBP between carriers of both CYP1A1-C3801 and AHR-A1661 alleles. CONCLUSION: This study is the first to show an interaction between the CYP1A1T3801C and AHRG1661A polymorphisms. This interaction could explain the difference in blood pressure level between smokers and non-smokers/ex-smokers but needs to be confirmed in a large sample.
Authors: Yun Ju Sung; Lisa de Las Fuentes; Thomas W Winkler; Daniel I Chasman; Amy R Bentley; Aldi T Kraja; Ioanna Ntalla; Helen R Warren; Xiuqing Guo; Karen Schwander; Alisa K Manning; Michael R Brown; Hugues Aschard; Mary F Feitosa; Nora Franceschini; Yingchang Lu; Ching-Yu Cheng; Xueling Sim; Dina Vojinovic; Jonathan Marten; Solomon K Musani; Tuomas O Kilpeläinen; Melissa A Richard; Stella Aslibekyan; Traci M Bartz; Rajkumar Dorajoo; Changwei Li; Yongmei Liu; Tuomo Rankinen; Albert Vernon Smith; Salman M Tajuddin; Bamidele O Tayo; Wei Zhao; Yanhua Zhou; Nana Matoba; Tamar Sofer; Maris Alver; Marzyeh Amini; Mathilde Boissel; Jin Fang Chai; Xu Chen; Jasmin Divers; Ilaria Gandin; Chuan Gao; Franco Giulianini; Anuj Goel; Sarah E Harris; Fernando P Hartwig; Meian He; Andrea R V R Horimoto; Fang-Chi Hsu; Anne U Jackson; Candace M Kammerer; Anuradhani Kasturiratne; Pirjo Komulainen; Brigitte Kühnel; Karin Leander; Wen-Jane Lee; Keng-Hung Lin; Jian'an Luan; Leo-Pekka Lyytikäinen; Colin A McKenzie; Christopher P Nelson; Raymond Noordam; Robert A Scott; Wayne H H Sheu; Alena Stančáková; Fumihiko Takeuchi; Peter J van der Most; Tibor V Varga; Robert J Waken; Heming Wang; Yajuan Wang; Erin B Ware; Stefan Weiss; Wanqing Wen; Lisa R Yanek; Weihua Zhang; Jing Hua Zhao; Saima Afaq; Tamuno Alfred; Najaf Amin; Dan E Arking; Tin Aung; R Graham Barr; Lawrence F Bielak; Eric Boerwinkle; Erwin P Bottinger; Peter S Braund; Jennifer A Brody; Ulrich Broeckel; Brian Cade; Archie Campbell; Mickaël Canouil; Aravinda Chakravarti; Massimiliano Cocca; Francis S Collins; John M Connell; Renée de Mutsert; H Janaka de Silva; Marcus Dörr; Qing Duan; Charles B Eaton; Georg Ehret; Evangelos Evangelou; Jessica D Faul; Nita G Forouhi; Oscar H Franco; Yechiel Friedlander; He Gao; Bruna Gigante; C Charles Gu; Preeti Gupta; Saskia P Hagenaars; Tamara B Harris; Jiang He; Sami Heikkinen; Chew-Kiat Heng; Albert Hofman; Barbara V Howard; Steven C Hunt; Marguerite R Irvin; Yucheng Jia; Tomohiro Katsuya; Joel Kaufman; Nicola D Kerrison; Chiea Chuen Khor; Woon-Puay Koh; Heikki A Koistinen; Charles B Kooperberg; Jose E Krieger; Michiaki Kubo; Zoltan Kutalik; Johanna Kuusisto; Timo A Lakka; Carl D Langefeld; Claudia Langenberg; Lenore J Launer; Joseph H Lee; Benjamin Lehne; Daniel Levy; Cora E Lewis; Yize Li; Sing Hui Lim; Ching-Ti Liu; Jianjun Liu; Jingmin Liu; Yeheng Liu; Marie Loh; Kurt K Lohman; Tin Louie; Reedik Mägi; Koichi Matsuda; Thomas Meitinger; Andres Metspalu; Lili Milani; Yukihide Momozawa; Thomas H Mosley; Mike A Nalls; Ubaydah Nasri; Jeff R O'Connell; Adesola Ogunniyi; Walter R Palmas; Nicholette D Palmer; James S Pankow; Nancy L Pedersen; Annette Peters; Patricia A Peyser; Ozren Polasek; David Porteous; Olli T Raitakari; Frida Renström; Treva K Rice; Paul M Ridker; Antonietta Robino; Jennifer G Robinson; Lynda M Rose; Igor Rudan; Charumathi Sabanayagam; Babatunde L Salako; Kevin Sandow; Carsten O Schmidt; Pamela J Schreiner; William R Scott; Peter Sever; Mario Sims; Colleen M Sitlani; Blair H Smith; Jennifer A Smith; Harold Snieder; John M Starr; Konstantin Strauch; Hua Tang; Kent D Taylor; Yik Ying Teo; Yih Chung Tham; André G Uitterlinden; Melanie Waldenberger; Lihua Wang; Ya Xing Wang; Wen Bin Wei; Gregory Wilson; Mary K Wojczynski; Yong-Bing Xiang; Jie Yao; Jian-Min Yuan; Alan B Zonderman; Diane M Becker; Michael Boehnke; Donald W Bowden; John C Chambers; Yii-Der Ida Chen; David R Weir; Ulf de Faire; Ian J Deary; Tõnu Esko; Martin Farrall; Terrence Forrester; Barry I Freedman; Philippe Froguel; Paolo Gasparini; Christian Gieger; Bernardo Lessa Horta; Yi-Jen Hung; Jost Bruno Jonas; Norihiro Kato; Jaspal S Kooner; Markku Laakso; Terho Lehtimäki; Kae-Woei Liang; Patrik K E Magnusson; Albertine J Oldehinkel; Alexandre C Pereira; Thomas Perls; Rainer Rauramaa; Susan Redline; Rainer Rettig; Nilesh J Samani; James Scott; Xiao-Ou Shu; Pim van der Harst; Lynne E Wagenknecht; Nicholas J Wareham; Hugh Watkins; Ananda R Wickremasinghe; Tangchun Wu; Yoichiro Kamatani; Cathy C Laurie; Claude Bouchard; Richard S Cooper; Michele K Evans; Vilmundur Gudnason; James Hixson; Sharon L R Kardia; Stephen B Kritchevsky; Bruce M Psaty; Rob M van Dam; Donna K Arnett; Dennis O Mook-Kanamori; Myriam Fornage; Ervin R Fox; Caroline Hayward; Cornelia M van Duijn; E Shyong Tai; Tien Yin Wong; Ruth J F Loos; Alex P Reiner; Charles N Rotimi; Laura J Bierut; Xiaofeng Zhu; L Adrienne Cupples; Michael A Province; Jerome I Rotter; Paul W Franks; Kenneth Rice; Paul Elliott; Mark J Caulfield; W James Gauderman; Patricia B Munroe; Dabeeru C Rao; Alanna C Morrison Journal: Hum Mol Genet Date: 2019-08-01 Impact factor: 6.150
Authors: Phillip G Kopf; Jason A Scott; Larry N Agbor; Jason R Boberg; Khalid M Elased; Janice K Huwe; Mary K Walker Journal: Toxicol Sci Date: 2010-07-15 Impact factor: 4.849