Literature DB >> 17052832

Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity.

Prabhu Sukumaran Nair1, C S Shyamala Devi.   

Abstract

The efficacy of mangiferin, on metabolism of lipids was tested in experimental cardiotoxic rats. The cardiotoxicity was induced by myocardial infarction through subcutaneous administration of isoproterenol hydrochloride for 2 days using 0.1 ml saline. Mangiferin drug was given as pretreatment for 28 days through intraperitonial administration using 0.2 ml dimethyl sulphoxide. Mangiferin significantly reduced the cholesterol, triglycerol, free fatty acids levels in serum and heart of the cardiotoxic myocardial infarcted rats. Mangiferin also increased the level of heart tissue phospholipids significantly in isoproterenol induced cardio toxic rats. The experiment thus concludes that mangiferin possess cardioprotective and hypolipidemic effect on experimentally induced cardiotoxic myocardial infarcted rats.

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Year:  2006        PMID： 17052832     DOI： 10.1016/j.tox.2006.08.030

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  6 in total

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Journal:  Inflammation       Date:  2022-07-28       Impact factor: 4.657

2.  Effects of Lagenaria sicessaria fruit juice on lipid profile and glycoprotein contents in cardiotoxicity induced by isoproterenol in rats.

Authors:  Aman Upaganlawar; R Balaraman
Journal:  Toxicol Int       Date:  2012-01

3.  Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices.

Authors:  Y N Zhang; J Wang; B Qi; S G Wu; H R Chen; H Y Luo; D J Yin; F J Lü; H J Zhang; G H Qi
Journal:  Asian-Australas J Anim Sci       Date:  2016-12-27       Impact factor: 2.509

4.  Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in Mangifera indica.

Authors:  P Naveen; H B Lingaraju; K Shyam Prasad
Journal:  Pharmacognosy Res       Date:  2017 Apr-Jun

Review 5.  Mangiferin: a natural miracle bioactive compound against lifestyle related disorders.

Authors:  Muhammad Imran; Muhammad Sajid Arshad; Masood Sadiq Butt; Joong-Ho Kwon; Muhammad Umair Arshad; Muhammad Tauseef Sultan
Journal:  Lipids Health Dis       Date:  2017-05-02       Impact factor: 3.876

6.  Citrus medica "Otroj": attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats.

Authors:  Mohammed A Al-Yahya; Ramzi A Mothana; Mansour S Al-Said; Kamal Elddin El-Tahir; Mohammed Al-Sohaibani; Syed Rafatullah
Journal:  Nutrients       Date:  2013-10-28       Impact factor: 5.717
  6 in total

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