Memory performance profile in occupational chronic solvent encephalopathy suggests working memory dysfunction.

This pilot study characterizes memory functioning of 11 men with occupational chronic solvent encephalopathy (CSE). Pattern (PRM) and spatial recognition (SRM), spatial span (SSP), spatial working memory (SWM), and paired associate learning (PAL) from Cambridge Neuropsychological Test Automated Battery were performed twice. The most sensitive variables to show impairment were PAL trials, SRM total correct, and SWM number of between-search errors. The majority of the CSE patients demonstrated mild deficits. The most persistent dysfunction was in tasks demanding working memory processing, which predicted well the CSE status. Qualitatively, the memory deficits resemble those seen in moderate or severe Parkinson's disease.