Nancy Fiedler1, Clifford Weisel, Chizoba Nwankwo, Howard Kipen, Gudrun Lange, Pamela Ohman-Strickland, Robert Laumbach. 1. Rutgers University, Environmental & Occupational Health Sciences Institute, Piscataway, New Jersey (Drs Fiedler, Weisel, Kipen, Laumbach), Rutgers University School of Public Health, Piscataway, New Jersey (Drs Fiedler, Weisel, Kipen, Laumbach, Ohman-Strickland), Merck & Company Inc., Kenilworth, New Jersey (Dr Nwankwo), Mount Sinai School of Medicine, Pain and Fatigue Study Center, New York, New York (Dr Lange).
Abstract
OBJECTIVE: The aim of this study was to assess the neurobehavioral effects of lifetime solvent exposure by comparing the performance of painters and demographically comparable controls. METHODS: Performance of exposed painters (N = 133) was compared with unexposed tapers, glaziers, or carpenters (N = 78) on the following domains: motor/perceptual speed, visual contrast, attention, working memory/planning, and visual and verbal memory. Lifetime exposure was estimated with questionnaires, field measurements, and paint composition. RESULTS: After controlling for confounders, lifetime solvent exposure did not predict reduction in performance for overall domains of function. Lifetime solvent exposures predicted subtle alterations for individual tests of verbal learning, motor coordination, and visuospatial accuracy. CONCLUSION: Concentrations of solvents in paints have steadily declined during the working lifetime of subjects in this study. Although reduced performance was observed on individual tests, these alterations were not consistent across tests and unlikely to be of clinical significance.
OBJECTIVE: The aim of this study was to assess the neurobehavioral effects of lifetime solvent exposure by comparing the performance of painters and demographically comparable controls. METHODS: Performance of exposed painters (N = 133) was compared with unexposed tapers, glaziers, or carpenters (N = 78) on the following domains: motor/perceptual speed, visual contrast, attention, working memory/planning, and visual and verbal memory. Lifetime exposure was estimated with questionnaires, field measurements, and paint composition. RESULTS: After controlling for confounders, lifetime solvent exposure did not predict reduction in performance for overall domains of function. Lifetime solvent exposures predicted subtle alterations for individual tests of verbal learning, motor coordination, and visuospatial accuracy. CONCLUSION: Concentrations of solvents in paints have steadily declined during the working lifetime of subjects in this study. Although reduced performance was observed on individual tests, these alterations were not consistent across tests and unlikely to be of clinical significance.
Authors: T W Robbins; M James; A M Owen; B J Sahakian; A D Lawrence; L McInnes; P M Rabbitt Journal: J Int Neuropsychol Soc Date: 1998-09 Impact factor: 2.892
Authors: Petra Keski-Säntti; Ari Kaukiainen; Hanna-Kaisa Hyvärinen; Markku Sainio Journal: Int Arch Occup Environ Health Date: 2009-11-26 Impact factor: 3.015
Authors: Nancy Fiedler; Clifford Weisel; Richard Lynch; Kathie Kelly-McNeil; Richard Wedeen; Keith Jones; Iris Udasin; Pamela Ohman-Strickland; Michael Gochfeld Journal: Am J Ind Med Date: 2003-10 Impact factor: 2.214